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PITX1 plays essential functions in cancer

PITX1, also known as the pituitary homeobox 1 gene, has emerged as a key regulator in animal growth and development, attracting significant research attention. Recent investigations have revealed the implication of dysregulated PITX1 expression in tumorigenesis, highlighting its involvement in cance...

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Detalles Bibliográficos
Autores principales: Zhao, Jingpu, Xu, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570508/
https://www.ncbi.nlm.nih.gov/pubmed/37841446
http://dx.doi.org/10.3389/fonc.2023.1253238
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author Zhao, Jingpu
Xu, Yongfeng
author_facet Zhao, Jingpu
Xu, Yongfeng
author_sort Zhao, Jingpu
collection PubMed
description PITX1, also known as the pituitary homeobox 1 gene, has emerged as a key regulator in animal growth and development, attracting significant research attention. Recent investigations have revealed the implication of dysregulated PITX1 expression in tumorigenesis, highlighting its involvement in cancer development. Notably, PITX1 interacts with p53 and exerts control over crucial cellular processes including cell cycle progression, apoptosis, and chemotherapy resistance. Its influence extends to various tumors, such as esophageal, colorectal, gastric, and liver cancer, contributing to tumor progression and metastasis. Despite its significance, a comprehensive review examining PITX1’s role in oncology remains lacking. This review aims to address this gap by providing a comprehensive overview of PITX1 in different cancer types, with a particular focus on its clinicopathological significance.
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spelling pubmed-105705082023-10-14 PITX1 plays essential functions in cancer Zhao, Jingpu Xu, Yongfeng Front Oncol Oncology PITX1, also known as the pituitary homeobox 1 gene, has emerged as a key regulator in animal growth and development, attracting significant research attention. Recent investigations have revealed the implication of dysregulated PITX1 expression in tumorigenesis, highlighting its involvement in cancer development. Notably, PITX1 interacts with p53 and exerts control over crucial cellular processes including cell cycle progression, apoptosis, and chemotherapy resistance. Its influence extends to various tumors, such as esophageal, colorectal, gastric, and liver cancer, contributing to tumor progression and metastasis. Despite its significance, a comprehensive review examining PITX1’s role in oncology remains lacking. This review aims to address this gap by providing a comprehensive overview of PITX1 in different cancer types, with a particular focus on its clinicopathological significance. Frontiers Media S.A. 2023-09-29 /pmc/articles/PMC10570508/ /pubmed/37841446 http://dx.doi.org/10.3389/fonc.2023.1253238 Text en Copyright © 2023 Zhao and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhao, Jingpu
Xu, Yongfeng
PITX1 plays essential functions in cancer
title PITX1 plays essential functions in cancer
title_full PITX1 plays essential functions in cancer
title_fullStr PITX1 plays essential functions in cancer
title_full_unstemmed PITX1 plays essential functions in cancer
title_short PITX1 plays essential functions in cancer
title_sort pitx1 plays essential functions in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570508/
https://www.ncbi.nlm.nih.gov/pubmed/37841446
http://dx.doi.org/10.3389/fonc.2023.1253238
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