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Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles
Alcoholic liver disease (ALD) poses a significant threat to human health, with excessive alcohol intake disrupting the immunotolerant environment of the liver and initiating a cascade of pathological events. This progressive disease unfolds through fat deposition, proinflammatory cytokine upregulati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570533/ https://www.ncbi.nlm.nih.gov/pubmed/37841267 http://dx.doi.org/10.3389/fimmu.2023.1205821 |
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author | Aghara, Hiral Chadha, Prashsti Zala, Devangi Mandal, Palash |
author_facet | Aghara, Hiral Chadha, Prashsti Zala, Devangi Mandal, Palash |
author_sort | Aghara, Hiral |
collection | PubMed |
description | Alcoholic liver disease (ALD) poses a significant threat to human health, with excessive alcohol intake disrupting the immunotolerant environment of the liver and initiating a cascade of pathological events. This progressive disease unfolds through fat deposition, proinflammatory cytokine upregulation, activation of hepatic stellate cells, and eventual development of end-stage liver disease, known as hepatocellular carcinoma (HCC). ALD is intricately intertwined with stress mechanisms such as oxidative stress mediated by reactive oxygen species, endoplasmic reticulum stress, and alcohol-induced gut dysbiosis, culminating in increased inflammation. While the initial stages of ALD can be reversible with diligent care and abstinence, further progression necessitates alternative treatment approaches. Herbal medicines have shown promise, albeit limited by their poor water solubility and subsequent lack of extensive exploration. Consequently, researchers have embarked on a quest to overcome these challenges by delving into the potential of nanoparticle-mediated therapy. Nanoparticle-based treatments are being explored for liver diseases that share similar mechanisms with alcoholic liver disease. It underscores the potential of these innovative approaches to counteract the complex pathogenesis of ALD, providing new avenues for therapeutic intervention. Nevertheless, further investigations are imperative to fully unravel the therapeutic potential and unlock the promise of nanoparticle-mediated therapy specifically tailored for ALD treatment. |
format | Online Article Text |
id | pubmed-10570533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105705332023-10-14 Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles Aghara, Hiral Chadha, Prashsti Zala, Devangi Mandal, Palash Front Immunol Immunology Alcoholic liver disease (ALD) poses a significant threat to human health, with excessive alcohol intake disrupting the immunotolerant environment of the liver and initiating a cascade of pathological events. This progressive disease unfolds through fat deposition, proinflammatory cytokine upregulation, activation of hepatic stellate cells, and eventual development of end-stage liver disease, known as hepatocellular carcinoma (HCC). ALD is intricately intertwined with stress mechanisms such as oxidative stress mediated by reactive oxygen species, endoplasmic reticulum stress, and alcohol-induced gut dysbiosis, culminating in increased inflammation. While the initial stages of ALD can be reversible with diligent care and abstinence, further progression necessitates alternative treatment approaches. Herbal medicines have shown promise, albeit limited by their poor water solubility and subsequent lack of extensive exploration. Consequently, researchers have embarked on a quest to overcome these challenges by delving into the potential of nanoparticle-mediated therapy. Nanoparticle-based treatments are being explored for liver diseases that share similar mechanisms with alcoholic liver disease. It underscores the potential of these innovative approaches to counteract the complex pathogenesis of ALD, providing new avenues for therapeutic intervention. Nevertheless, further investigations are imperative to fully unravel the therapeutic potential and unlock the promise of nanoparticle-mediated therapy specifically tailored for ALD treatment. Frontiers Media S.A. 2023-09-29 /pmc/articles/PMC10570533/ /pubmed/37841267 http://dx.doi.org/10.3389/fimmu.2023.1205821 Text en Copyright © 2023 Aghara, Chadha, Zala and Mandal https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Aghara, Hiral Chadha, Prashsti Zala, Devangi Mandal, Palash Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles |
title | Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles |
title_full | Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles |
title_fullStr | Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles |
title_full_unstemmed | Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles |
title_short | Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles |
title_sort | stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570533/ https://www.ncbi.nlm.nih.gov/pubmed/37841267 http://dx.doi.org/10.3389/fimmu.2023.1205821 |
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