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Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study

Uncontrolled and unsafe use of pesticides can lead to acute and chronic toxicity in farmers, with neuropathy being one of the most common symptoms of chronic toxicity. However, the effects of this toxicity on farmers' electroneuromyography (ENMG) are still unclear. To address this, we conducted...

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Autores principales: Panggabean, Andre Stefanus, Setyopranoto, Ismail, Wicaksono, Arjanto Ramadian, Rismawan, Alfian, Dwianingsih, Ery Kus, Tama, Whisnu Nalendra, Gofir, Abdul, Setyaningrum, Cempaka Thursina Srie, Sutarni, Sri, Asmedi, Ahmad, Rhamadianti, Aulia Fitri, Bawono, Rheza Gandi, Malueka, Rusdy Ghazali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570540/
https://www.ncbi.nlm.nih.gov/pubmed/37840896
http://dx.doi.org/10.1016/j.toxrep.2023.09.020
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author Panggabean, Andre Stefanus
Setyopranoto, Ismail
Wicaksono, Arjanto Ramadian
Rismawan, Alfian
Dwianingsih, Ery Kus
Tama, Whisnu Nalendra
Gofir, Abdul
Setyaningrum, Cempaka Thursina Srie
Sutarni, Sri
Asmedi, Ahmad
Rhamadianti, Aulia Fitri
Bawono, Rheza Gandi
Malueka, Rusdy Ghazali
author_facet Panggabean, Andre Stefanus
Setyopranoto, Ismail
Wicaksono, Arjanto Ramadian
Rismawan, Alfian
Dwianingsih, Ery Kus
Tama, Whisnu Nalendra
Gofir, Abdul
Setyaningrum, Cempaka Thursina Srie
Sutarni, Sri
Asmedi, Ahmad
Rhamadianti, Aulia Fitri
Bawono, Rheza Gandi
Malueka, Rusdy Ghazali
author_sort Panggabean, Andre Stefanus
collection PubMed
description Uncontrolled and unsafe use of pesticides can lead to acute and chronic toxicity in farmers, with neuropathy being one of the most common symptoms of chronic toxicity. However, the effects of this toxicity on farmers' electroneuromyography (ENMG) are still unclear. To address this, we conducted a cross-sectional study from July to October 2017 in Ngablak District, Magelang, Central Java, Indonesia. Eligible farmers who were exposed to pesticides underwent electrophysiology examinations, as well as additional tests such as physical examination and laboratory testing. We collected general information such as age and work history by interview. In total, 64 farmers were included in this study. Out of these, 44 farmers were found to have polyneuropathy, with 41 of them having motor polyneuropathy and 19 of them having sensory polyneuropathy. Our findings showed that low blood cholinesterase was associated with distal latency prolongation (p-value: 0.014). The group exposed to organophosphate/carbamate pesticides was also significantly associated with prolonged distal latency (p-value: 0.012). However, motor polyneuropathy was significantly associated with chronic exposure to organophosphate/carbamate pesticides (p-value: 0.009) and not with low blood cholinesterase levels (p-value: 0.454). The study concludes that chronic exposure to organophosphate or carbamate pesticides could result in polyneuropathy disease, particularly in the motor system.
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spelling pubmed-105705402023-10-14 Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study Panggabean, Andre Stefanus Setyopranoto, Ismail Wicaksono, Arjanto Ramadian Rismawan, Alfian Dwianingsih, Ery Kus Tama, Whisnu Nalendra Gofir, Abdul Setyaningrum, Cempaka Thursina Srie Sutarni, Sri Asmedi, Ahmad Rhamadianti, Aulia Fitri Bawono, Rheza Gandi Malueka, Rusdy Ghazali Toxicol Rep Article Uncontrolled and unsafe use of pesticides can lead to acute and chronic toxicity in farmers, with neuropathy being one of the most common symptoms of chronic toxicity. However, the effects of this toxicity on farmers' electroneuromyography (ENMG) are still unclear. To address this, we conducted a cross-sectional study from July to October 2017 in Ngablak District, Magelang, Central Java, Indonesia. Eligible farmers who were exposed to pesticides underwent electrophysiology examinations, as well as additional tests such as physical examination and laboratory testing. We collected general information such as age and work history by interview. In total, 64 farmers were included in this study. Out of these, 44 farmers were found to have polyneuropathy, with 41 of them having motor polyneuropathy and 19 of them having sensory polyneuropathy. Our findings showed that low blood cholinesterase was associated with distal latency prolongation (p-value: 0.014). The group exposed to organophosphate/carbamate pesticides was also significantly associated with prolonged distal latency (p-value: 0.012). However, motor polyneuropathy was significantly associated with chronic exposure to organophosphate/carbamate pesticides (p-value: 0.009) and not with low blood cholinesterase levels (p-value: 0.454). The study concludes that chronic exposure to organophosphate or carbamate pesticides could result in polyneuropathy disease, particularly in the motor system. Elsevier 2023-10-03 /pmc/articles/PMC10570540/ /pubmed/37840896 http://dx.doi.org/10.1016/j.toxrep.2023.09.020 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Panggabean, Andre Stefanus
Setyopranoto, Ismail
Wicaksono, Arjanto Ramadian
Rismawan, Alfian
Dwianingsih, Ery Kus
Tama, Whisnu Nalendra
Gofir, Abdul
Setyaningrum, Cempaka Thursina Srie
Sutarni, Sri
Asmedi, Ahmad
Rhamadianti, Aulia Fitri
Bawono, Rheza Gandi
Malueka, Rusdy Ghazali
Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study
title Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study
title_full Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study
title_fullStr Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study
title_full_unstemmed Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study
title_short Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study
title_sort neuropathy caused by pesticide exposure on farmers in ngablak district, magelang, central java, indonesia: an electroneuromyography study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570540/
https://www.ncbi.nlm.nih.gov/pubmed/37840896
http://dx.doi.org/10.1016/j.toxrep.2023.09.020
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