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Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study
Uncontrolled and unsafe use of pesticides can lead to acute and chronic toxicity in farmers, with neuropathy being one of the most common symptoms of chronic toxicity. However, the effects of this toxicity on farmers' electroneuromyography (ENMG) are still unclear. To address this, we conducted...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570540/ https://www.ncbi.nlm.nih.gov/pubmed/37840896 http://dx.doi.org/10.1016/j.toxrep.2023.09.020 |
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author | Panggabean, Andre Stefanus Setyopranoto, Ismail Wicaksono, Arjanto Ramadian Rismawan, Alfian Dwianingsih, Ery Kus Tama, Whisnu Nalendra Gofir, Abdul Setyaningrum, Cempaka Thursina Srie Sutarni, Sri Asmedi, Ahmad Rhamadianti, Aulia Fitri Bawono, Rheza Gandi Malueka, Rusdy Ghazali |
author_facet | Panggabean, Andre Stefanus Setyopranoto, Ismail Wicaksono, Arjanto Ramadian Rismawan, Alfian Dwianingsih, Ery Kus Tama, Whisnu Nalendra Gofir, Abdul Setyaningrum, Cempaka Thursina Srie Sutarni, Sri Asmedi, Ahmad Rhamadianti, Aulia Fitri Bawono, Rheza Gandi Malueka, Rusdy Ghazali |
author_sort | Panggabean, Andre Stefanus |
collection | PubMed |
description | Uncontrolled and unsafe use of pesticides can lead to acute and chronic toxicity in farmers, with neuropathy being one of the most common symptoms of chronic toxicity. However, the effects of this toxicity on farmers' electroneuromyography (ENMG) are still unclear. To address this, we conducted a cross-sectional study from July to October 2017 in Ngablak District, Magelang, Central Java, Indonesia. Eligible farmers who were exposed to pesticides underwent electrophysiology examinations, as well as additional tests such as physical examination and laboratory testing. We collected general information such as age and work history by interview. In total, 64 farmers were included in this study. Out of these, 44 farmers were found to have polyneuropathy, with 41 of them having motor polyneuropathy and 19 of them having sensory polyneuropathy. Our findings showed that low blood cholinesterase was associated with distal latency prolongation (p-value: 0.014). The group exposed to organophosphate/carbamate pesticides was also significantly associated with prolonged distal latency (p-value: 0.012). However, motor polyneuropathy was significantly associated with chronic exposure to organophosphate/carbamate pesticides (p-value: 0.009) and not with low blood cholinesterase levels (p-value: 0.454). The study concludes that chronic exposure to organophosphate or carbamate pesticides could result in polyneuropathy disease, particularly in the motor system. |
format | Online Article Text |
id | pubmed-10570540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105705402023-10-14 Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study Panggabean, Andre Stefanus Setyopranoto, Ismail Wicaksono, Arjanto Ramadian Rismawan, Alfian Dwianingsih, Ery Kus Tama, Whisnu Nalendra Gofir, Abdul Setyaningrum, Cempaka Thursina Srie Sutarni, Sri Asmedi, Ahmad Rhamadianti, Aulia Fitri Bawono, Rheza Gandi Malueka, Rusdy Ghazali Toxicol Rep Article Uncontrolled and unsafe use of pesticides can lead to acute and chronic toxicity in farmers, with neuropathy being one of the most common symptoms of chronic toxicity. However, the effects of this toxicity on farmers' electroneuromyography (ENMG) are still unclear. To address this, we conducted a cross-sectional study from July to October 2017 in Ngablak District, Magelang, Central Java, Indonesia. Eligible farmers who were exposed to pesticides underwent electrophysiology examinations, as well as additional tests such as physical examination and laboratory testing. We collected general information such as age and work history by interview. In total, 64 farmers were included in this study. Out of these, 44 farmers were found to have polyneuropathy, with 41 of them having motor polyneuropathy and 19 of them having sensory polyneuropathy. Our findings showed that low blood cholinesterase was associated with distal latency prolongation (p-value: 0.014). The group exposed to organophosphate/carbamate pesticides was also significantly associated with prolonged distal latency (p-value: 0.012). However, motor polyneuropathy was significantly associated with chronic exposure to organophosphate/carbamate pesticides (p-value: 0.009) and not with low blood cholinesterase levels (p-value: 0.454). The study concludes that chronic exposure to organophosphate or carbamate pesticides could result in polyneuropathy disease, particularly in the motor system. Elsevier 2023-10-03 /pmc/articles/PMC10570540/ /pubmed/37840896 http://dx.doi.org/10.1016/j.toxrep.2023.09.020 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Panggabean, Andre Stefanus Setyopranoto, Ismail Wicaksono, Arjanto Ramadian Rismawan, Alfian Dwianingsih, Ery Kus Tama, Whisnu Nalendra Gofir, Abdul Setyaningrum, Cempaka Thursina Srie Sutarni, Sri Asmedi, Ahmad Rhamadianti, Aulia Fitri Bawono, Rheza Gandi Malueka, Rusdy Ghazali Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study |
title | Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study |
title_full | Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study |
title_fullStr | Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study |
title_full_unstemmed | Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study |
title_short | Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study |
title_sort | neuropathy caused by pesticide exposure on farmers in ngablak district, magelang, central java, indonesia: an electroneuromyography study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570540/ https://www.ncbi.nlm.nih.gov/pubmed/37840896 http://dx.doi.org/10.1016/j.toxrep.2023.09.020 |
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