CRISPR deletion of a SINE-VNTR-Alu (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the MAPT locus

BACKGROUND: SINE-VNTR-Alu (SVA) retrotransposons are hominid-specific elements which have been shown to play important roles in processes such as chromatin structure remodelling and regulation of gene expression demonstrating that these repetitive elements exert regulatory functions. We have previou...

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Detalles Bibliográficos
Autores principales: Fröhlich, Alexander, Hughes, Lauren S., Middlehurst, Ben, Pfaff, Abigail L., Bubb, Vivien J., Koks, Sulev, Quinn, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570551/
https://www.ncbi.nlm.nih.gov/pubmed/37840928
http://dx.doi.org/10.3389/fneur.2023.1273036

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