Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape

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Current capabilities in genomic sequencing outpace functional interpretations. Our previous work showed that 3D protein structure calculations enhance mechanistic understanding of genetic variation in sequenced tumors and patients with rare diseases. The KRAS GTPase is among the critical genetic fac...

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Detalles Bibliográficos
Autores principales: Ratnasinghe, Brian D., Haque, Neshatul, Wagenknecht, Jessica B., Jensen, Davin R., Valdivia Esparza, Guadalupe K., Leverence, Elise N., Milech De Assuncao, Thiago, Mathison, Angela J., Lomberk, Gwen, Smith, Brian C., Volkman, Brian F., Urrutia, Raul, Zimmermann, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570560/
https://www.ncbi.nlm.nih.gov/pubmed/37841325
http://dx.doi.org/10.1016/j.csbj.2023.10.003
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