Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer

PURPOSE: High tumor production of the EGFR ligands, amphiregulin (AREG) and epiregulin (EREG), predicted benefit from anti-EGFR therapy for metastatic colorectal cancer (mCRC) in a retrospective analysis of clinical trial data. Here, AREG/EREG IHC was analyzed in a cohort of patients who received an...

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Detalles Bibliográficos
Autores principales: Williams, Christopher J.M., Elliott, Faye, Sapanara, Nancy, Aghaei, Faranak, Zhang, Liping, Muranyi, Andrea, Yan, Dongyao, Bai, Isaac, Zhao, Zuo, Shires, Michael, Wood, Henry M., Richman, Susan D., Hemmings, Gemma, Hale, Michael, Bottomley, Daniel, Galvin, Leanne, Cartlidge, Caroline, Dance, Sarah, Bacon, Chris M., Mansfield, Laura, Young-Zvandasara, Kathe, Sudan, Ajay, Lambert, Katy, Bibby, Irena, Coupland, Sarah E., Montazeri, Amir, Kipling, Natalie, Hughes, Kathryn, Cross, Simon S., Dewdney, Alice, Pheasey, Leanne, Leng, Cathryn, Gochera, Tatenda, Mangham, D. Chas, Saunders, Mark, Pritchard, Martin, Stott, Helen, Mukherjee, Abhik, Ilyas, Mohammad, Silverman, Rafael, Hyland, Georgina, Sculthorpe, Declan, Thornton, Kirsty, Gould, Imogen, O'Callaghan, Ann, Brown, Nicholas, Turnbull, Samantha, Shaw, Lisa, Seymour, Matthew T., West, Nicholas P., Seligmann, Jenny F., Singh, Shalini, Shanmugam, Kandavel, Quirke, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570673/
https://www.ncbi.nlm.nih.gov/pubmed/37363997
http://dx.doi.org/10.1158/1078-0432.CCR-23-0859

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