Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

Although external beam radiotherapy (xRT) is commonly used to treat central nervous system (CNS) tumors in patients of all ages, young children treated with xRT frequently experience life-altering and dose-limiting neurocognitive impairment (NI) while adults do not. The lack of understanding of mech...

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Detalles Bibliográficos
Autores principales: Singh, Rumani, Yu, Stacey, Osman, Marwa, Inde, Zintis, Fraser, Cameron, Cleveland, Abigail H., Almanzar, Nicole, Lim, Chuan Bian, Joshi, Gaurav N., Spetz, Johan, Qin, Xingping, Toprani, Sneh M., Nagel, Zachary, Hocking, Matthew C., Cormack, Robert A., Yock, Torunn I., Miller, Jeffrey W., Yuan, Zhi-Min, Gershon, Timothy, Sarosiek, Kristopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570680/
https://www.ncbi.nlm.nih.gov/pubmed/37470810
http://dx.doi.org/10.1158/0008-5472.CAN-22-1337

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