Secondary somatic glioblastoma arising from a mature ovarian cystic teratoma in a patient with underlying Li-Fraumeni syndrome

• First report of a secondary somatic glioblastoma arising from MCT-MT in a patient with underlying Li-Fraumeni syndrome. • The rarity of glioblastoma arising from MCT-MT warrants investigation for underlying genetic predisposition. • Glioblastomas arising from MCT-MT appear to exhibit wild type IDH gene status. • Advanced-stage glioblastoma arising from MCT-MT exhibits aggressive behavior and requires adjuvant therapy. • Optimal adjuvant therapy regimen for glioblastoma arising from MCT-MT remains unknown.