Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

OBJECTIVE: ASCL1, a pioneer transcription factor, is essential for neural cell differentiation and function. Previous studies have shown that Ascl1 expression is increased in pancreatic β-cells lacking functional K(ATP) channels or after feeding of a high fat diet (HFD) suggesting that it may contri...

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Detalles Bibliográficos
Autores principales: Osipovich, Anna B., Zhou, Frank Y., Chong, Judy J., Trinh, Linh T., Cottam, Mathew A., Shrestha, Shristi, Cartailler, Jean-Philippe, Magnuson, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570713/
https://www.ncbi.nlm.nih.gov/pubmed/37769990
http://dx.doi.org/10.1016/j.molmet.2023.101811

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