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Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid

BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive/stereotyped behaviors. Its prevalence is increasing, affecting one in 36 children in the United States. The valproic acid (VPA) induced animal model of ASD is a re...

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Autores principales: Schwingel, Gustavo Brum, Fontes-Dutra, Mellanie, Ramos, Bárbara, Riesgo, Rudimar, Bambini-Junior, Victorio, Gottfried, Carmem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570715/
https://www.ncbi.nlm.nih.gov/pubmed/37841088
http://dx.doi.org/10.1016/j.ibneur.2023.09.008
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author Schwingel, Gustavo Brum
Fontes-Dutra, Mellanie
Ramos, Bárbara
Riesgo, Rudimar
Bambini-Junior, Victorio
Gottfried, Carmem
author_facet Schwingel, Gustavo Brum
Fontes-Dutra, Mellanie
Ramos, Bárbara
Riesgo, Rudimar
Bambini-Junior, Victorio
Gottfried, Carmem
author_sort Schwingel, Gustavo Brum
collection PubMed
description BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive/stereotyped behaviors. Its prevalence is increasing, affecting one in 36 children in the United States. The valproic acid (VPA) induced animal model of ASD is a reliable method for investigating cellular, molecular, and behavioral aspects related to the disorder. Trans-Resveratrol (RSV), a polyphenol with anti-inflammatory and antioxidant effects studied in various diseases, has recently demonstrated the ability to prevent cellular, molecular, sensory, and social deficits in the VPA model. In this study, we examined the effects of prenatal exposure to VPA and the potential preventive effects of RSV on the offspring. METHOD: We monitored gestational weight from embryonic day 6.5 until 18.5 and assessed the onset of developmental milestones and morphometric parameters in litters. The generalized estimating equations (GEE) were used to analyze longitudinal data. RESULTS: Exposure to VPA during rat pregnancy resulted in abnormal weight gain fold-changes on embryonic days 13.5 and 18.5, followed by fewer animals per litter. Additionally, we discovered a positive correlation between weight variation during E15.5-E18.5 and the number of rat pups in the VPA group. CONCLUSION: VPA exposure led to slight length deficiencies and delays in the onset of developmental milestones. Interestingly, the prenatal RSV treatment not only prevented most of these delays but also led to the early onset of certain milestones and improved morphometric characteristics in the offspring. In summary, our findings suggest that RSV may have potential as a therapeutic intervention to protect against the negative effects of prenatal VPA exposure, highlighting its importance in future studies of prenatal neurodevelopmental disorders.
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spelling pubmed-105707152023-10-14 Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid Schwingel, Gustavo Brum Fontes-Dutra, Mellanie Ramos, Bárbara Riesgo, Rudimar Bambini-Junior, Victorio Gottfried, Carmem IBRO Neurosci Rep Research Paper BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive/stereotyped behaviors. Its prevalence is increasing, affecting one in 36 children in the United States. The valproic acid (VPA) induced animal model of ASD is a reliable method for investigating cellular, molecular, and behavioral aspects related to the disorder. Trans-Resveratrol (RSV), a polyphenol with anti-inflammatory and antioxidant effects studied in various diseases, has recently demonstrated the ability to prevent cellular, molecular, sensory, and social deficits in the VPA model. In this study, we examined the effects of prenatal exposure to VPA and the potential preventive effects of RSV on the offspring. METHOD: We monitored gestational weight from embryonic day 6.5 until 18.5 and assessed the onset of developmental milestones and morphometric parameters in litters. The generalized estimating equations (GEE) were used to analyze longitudinal data. RESULTS: Exposure to VPA during rat pregnancy resulted in abnormal weight gain fold-changes on embryonic days 13.5 and 18.5, followed by fewer animals per litter. Additionally, we discovered a positive correlation between weight variation during E15.5-E18.5 and the number of rat pups in the VPA group. CONCLUSION: VPA exposure led to slight length deficiencies and delays in the onset of developmental milestones. Interestingly, the prenatal RSV treatment not only prevented most of these delays but also led to the early onset of certain milestones and improved morphometric characteristics in the offspring. In summary, our findings suggest that RSV may have potential as a therapeutic intervention to protect against the negative effects of prenatal VPA exposure, highlighting its importance in future studies of prenatal neurodevelopmental disorders. Elsevier 2023-09-23 /pmc/articles/PMC10570715/ /pubmed/37841088 http://dx.doi.org/10.1016/j.ibneur.2023.09.008 Text en © 2023 Published by Elsevier Ltd on behalf of International Brain Research Organization. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Schwingel, Gustavo Brum
Fontes-Dutra, Mellanie
Ramos, Bárbara
Riesgo, Rudimar
Bambini-Junior, Victorio
Gottfried, Carmem
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
title Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
title_full Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
title_fullStr Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
title_full_unstemmed Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
title_short Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
title_sort preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570715/
https://www.ncbi.nlm.nih.gov/pubmed/37841088
http://dx.doi.org/10.1016/j.ibneur.2023.09.008
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