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Electrochemical Late-Stage Functionalization

[Image: see text] Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or diversification of novel molecular entities with improved physicochemical or biological activities. LSF can thus greatly accelerate the development of medicinally relevant compounds, crop protect...

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Detalles Bibliográficos
Autores principales: Wang, Yulei, Dana, Suman, Long, Hao, Xu, Yang, Li, Yanjun, Kaplaneris, Nikolaos, Ackermann, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571048/
https://www.ncbi.nlm.nih.gov/pubmed/37751573
http://dx.doi.org/10.1021/acs.chemrev.3c00158
Descripción
Sumario:[Image: see text] Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or diversification of novel molecular entities with improved physicochemical or biological activities. LSF can thus greatly accelerate the development of medicinally relevant compounds, crop protecting agents, and functional materials. Electrochemical molecular synthesis has emerged as an environmentally friendly platform for the transformation of organic compounds. Over the past decade, electrochemical late-stage functionalization (eLSF) has gained major momentum, which is summarized herein up to February 2023.