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Conditional knockout of PDK1 in osteoclasts suppressed osteoclastogenesis and ameliorated prostate cancer-induced osteolysis in murine model

BACKGROUND: The development and maintenance of normal bone tissue is maintained by balanced communication between osteoblasts and osteoclasts. The invasion of cancer cells disrupts this balance, leading to osteolysis. As the only bone resorbing cells in vivo, osteoclasts play important roles in canc...

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Detalles Bibliográficos
Autores principales:	Zhang, Yanan, Nong, Haibin, Bai, Yiguang, Zhou, Quan, Zhang, Qiong, Liu, Mingfu, Liu, Pan, Zeng, Gaofeng, Zong, Shaohui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571267/ https://www.ncbi.nlm.nih.gov/pubmed/37828580 http://dx.doi.org/10.1186/s40001-023-01425-8

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