The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection

BACKGROUND: Existing methods to detect tumor signal in liquid biopsy have focused on the analysis of nuclear cell-free DNA (cfDNA). However, non-nuclear cfDNA and in particular mitochondrial DNA (mtDNA) has been understudied. We hypothesize that an increase in mtDNA in plasma could reflect the prese...

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Detalles Bibliográficos
Autores principales: van der Pol, Ymke, Moldovan, Norbert, Ramaker, Jip, Bootsma, Sanne, Lenos, Kristiaan J., Vermeulen, Louis, Sandhu, Shahneen, Bahce, Idris, Pegtel, D. Michiel, Wong, Stephen Q., Dawson, Sarah-Jane, Chandrananda, Dineika, Mouliere, Florent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571306/
https://www.ncbi.nlm.nih.gov/pubmed/37828498
http://dx.doi.org/10.1186/s13059-023-03074-w

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