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Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials
OBJECTIVES: Pervious epidemiologic evidence indicates that soluble fiber is protective against hypertention: however, randomized controlled trials (RCTs) have presented varying results. In the present study, we aimed to conduct a systematic review and dose–response meta-analysis to summarize publish...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571351/ https://www.ncbi.nlm.nih.gov/pubmed/37833676 http://dx.doi.org/10.1186/s12937-023-00879-0 |
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author | Ghavami, Abed Banpouri, Sara Ziaei, Rahele Talebi, Sepide Vajdi, Mahdi Nattagh‐Eshtivani, Elyas Barghchi, Hanieh Mohammadi, Hamed Askari, Gholamreza |
author_facet | Ghavami, Abed Banpouri, Sara Ziaei, Rahele Talebi, Sepide Vajdi, Mahdi Nattagh‐Eshtivani, Elyas Barghchi, Hanieh Mohammadi, Hamed Askari, Gholamreza |
author_sort | Ghavami, Abed |
collection | PubMed |
description | OBJECTIVES: Pervious epidemiologic evidence indicates that soluble fiber is protective against hypertention: however, randomized controlled trials (RCTs) have presented varying results. In the present study, we aimed to conduct a systematic review and dose–response meta-analysis to summarize published RCTs which assess the effect of soluble fiber supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). METHODS: Scopus, PubMed, and ISI Web of Sciences were searched to identify relevant studies up to Aug 2022. We estimated the change in blood pressure for each 5 g/d increment in soluble fiber supplementation in each trial and then calculated the weighted mean difference (WMD) and 95%CI using a random-effects model. We estimated dose-dependent effects using a dose–response meta-analysis of differences in means. The risk of bias for study was assessed using the Cochrane tool. Publication bias was evaluated via funnel plot and Begg’s test and Egger's test. RESULTS: Eighty-three eligible studies with total sample size of 5,985 participants were included in the meta-analysis. Soluble fiber supplementation significantly decreased SBP (WMD: -1.36 mmHg, 95% CI: -2.13 to -0.60, P < 0.001; I(2) = 47.1%, P < 0.001) and DBP (WMD: -0.72 mmHg, 95% CI: -1.26 to -0.18, P = 0.009; I(2) = 45.4%, P < 0.001). Each 5 g/d increment in soluble fiber supplementation had a significant reduction in SBP (WMD: -0.54 mmHg; 95%CI: -0.86, -0.22, P = 0.001; I(2) = 52.2, P(het) < 0.001) and DBP (WMD: -0.28 mmHg; 95%CI: -0.49, -0.80, P = 0.007; I(2) = 43.1%, P(het) < 0.001). The levels of SBP decreased proportionally with the increase in soluble fiber supplementation up to 20 g/d (MD(20g/d): -1.79 mmHg, 95%CI: -2.86, -0.71). CONCLUSION: Current evidence indicated the beneficial effect of soluble fiber supplementation on blood pressure. Our findings suggest that soluble fiber supplementation could contribute to the management of hypertension and the reduction of cardiovascular disease risk. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12937-023-00879-0. |
format | Online Article Text |
id | pubmed-10571351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105713512023-10-14 Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials Ghavami, Abed Banpouri, Sara Ziaei, Rahele Talebi, Sepide Vajdi, Mahdi Nattagh‐Eshtivani, Elyas Barghchi, Hanieh Mohammadi, Hamed Askari, Gholamreza Nutr J Review OBJECTIVES: Pervious epidemiologic evidence indicates that soluble fiber is protective against hypertention: however, randomized controlled trials (RCTs) have presented varying results. In the present study, we aimed to conduct a systematic review and dose–response meta-analysis to summarize published RCTs which assess the effect of soluble fiber supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). METHODS: Scopus, PubMed, and ISI Web of Sciences were searched to identify relevant studies up to Aug 2022. We estimated the change in blood pressure for each 5 g/d increment in soluble fiber supplementation in each trial and then calculated the weighted mean difference (WMD) and 95%CI using a random-effects model. We estimated dose-dependent effects using a dose–response meta-analysis of differences in means. The risk of bias for study was assessed using the Cochrane tool. Publication bias was evaluated via funnel plot and Begg’s test and Egger's test. RESULTS: Eighty-three eligible studies with total sample size of 5,985 participants were included in the meta-analysis. Soluble fiber supplementation significantly decreased SBP (WMD: -1.36 mmHg, 95% CI: -2.13 to -0.60, P < 0.001; I(2) = 47.1%, P < 0.001) and DBP (WMD: -0.72 mmHg, 95% CI: -1.26 to -0.18, P = 0.009; I(2) = 45.4%, P < 0.001). Each 5 g/d increment in soluble fiber supplementation had a significant reduction in SBP (WMD: -0.54 mmHg; 95%CI: -0.86, -0.22, P = 0.001; I(2) = 52.2, P(het) < 0.001) and DBP (WMD: -0.28 mmHg; 95%CI: -0.49, -0.80, P = 0.007; I(2) = 43.1%, P(het) < 0.001). The levels of SBP decreased proportionally with the increase in soluble fiber supplementation up to 20 g/d (MD(20g/d): -1.79 mmHg, 95%CI: -2.86, -0.71). CONCLUSION: Current evidence indicated the beneficial effect of soluble fiber supplementation on blood pressure. Our findings suggest that soluble fiber supplementation could contribute to the management of hypertension and the reduction of cardiovascular disease risk. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12937-023-00879-0. BioMed Central 2023-10-13 /pmc/articles/PMC10571351/ /pubmed/37833676 http://dx.doi.org/10.1186/s12937-023-00879-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Ghavami, Abed Banpouri, Sara Ziaei, Rahele Talebi, Sepide Vajdi, Mahdi Nattagh‐Eshtivani, Elyas Barghchi, Hanieh Mohammadi, Hamed Askari, Gholamreza Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials |
title | Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials |
title_full | Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials |
title_fullStr | Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials |
title_full_unstemmed | Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials |
title_short | Effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials |
title_sort | effect of soluble fiber on blood pressure in adults: a systematic review and dose–response meta-analysis of randomized controlled trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571351/ https://www.ncbi.nlm.nih.gov/pubmed/37833676 http://dx.doi.org/10.1186/s12937-023-00879-0 |
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