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Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma

BACKGROUND: The Parkinson’s disease (PD) gene family expression is strongly linked to tumor development and progression; PINK1 and PARK2 are essential members of the PD gene family. However, the relationship between PINK1 and PARK2 and esophageal squamous cell carcinoma (ESCC) remains unknown. This...

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Autores principales: Lu, Xiangyun, Yao, Yongkun, Ma, Yandi, Zhang, Xudong, Peng, Hao, Pei, Yuhui, Lu, Yulin, Wang, Lianghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571472/
https://www.ncbi.nlm.nih.gov/pubmed/37833780
http://dx.doi.org/10.1186/s12957-023-03206-3
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author Lu, Xiangyun
Yao, Yongkun
Ma, Yandi
Zhang, Xudong
Peng, Hao
Pei, Yuhui
Lu, Yulin
Wang, Lianghai
author_facet Lu, Xiangyun
Yao, Yongkun
Ma, Yandi
Zhang, Xudong
Peng, Hao
Pei, Yuhui
Lu, Yulin
Wang, Lianghai
author_sort Lu, Xiangyun
collection PubMed
description BACKGROUND: The Parkinson’s disease (PD) gene family expression is strongly linked to tumor development and progression; PINK1 and PARK2 are essential members of the PD gene family. However, the relationship between PINK1 and PARK2 and esophageal squamous cell carcinoma (ESCC) remains unknown. This research aims to clarify the prognostic value of PINK1 and PARK2 in ESCC. METHODS: PINK1 and PARK2 protein levels in 232 ESCC specimens, and 125 matched adjacent normal tissues were detected by immunohistochemistry. The relationship between PINK1 and PARK2 protein expression and clinicopathological features were analyzed. Kaplan–Meier survival analysis was performed to estimate the prognostic value of the PINK1 and PARK2 proteins in patients. Cox univariate and multivariate analyses were used to assess the risk factors affecting the OS for patients with ESCC. RESULTS: PINK1 and PARK2 had low expression in ESCC. Patients with low PINK1 had worse differentiation and advanced T and TNM stages. Lower PARK2 expression was linked to lymph node metastases and an advanced TNM stage. Furthermore, reduced PINK1 and PARK2 levels were associated with a poor prognosis for ESCC. Cox univariate and multivariate analyses revealed that PINK1, PARK2, and tumor size were closely associated with the prognosis of patients with ESCC, and PARK2 was an independent risk factor for patients with ESCC. Finally, the PINK1 and PARK2 proteins were closely related and shared the same signal pathway. CONCLUSIONS: PINK1 and PARK2 could work as tumor suppressors in ESCC and are likely to become new treatment targets for ESCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-03206-3.
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spelling pubmed-105714722023-10-14 Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma Lu, Xiangyun Yao, Yongkun Ma, Yandi Zhang, Xudong Peng, Hao Pei, Yuhui Lu, Yulin Wang, Lianghai World J Surg Oncol Research BACKGROUND: The Parkinson’s disease (PD) gene family expression is strongly linked to tumor development and progression; PINK1 and PARK2 are essential members of the PD gene family. However, the relationship between PINK1 and PARK2 and esophageal squamous cell carcinoma (ESCC) remains unknown. This research aims to clarify the prognostic value of PINK1 and PARK2 in ESCC. METHODS: PINK1 and PARK2 protein levels in 232 ESCC specimens, and 125 matched adjacent normal tissues were detected by immunohistochemistry. The relationship between PINK1 and PARK2 protein expression and clinicopathological features were analyzed. Kaplan–Meier survival analysis was performed to estimate the prognostic value of the PINK1 and PARK2 proteins in patients. Cox univariate and multivariate analyses were used to assess the risk factors affecting the OS for patients with ESCC. RESULTS: PINK1 and PARK2 had low expression in ESCC. Patients with low PINK1 had worse differentiation and advanced T and TNM stages. Lower PARK2 expression was linked to lymph node metastases and an advanced TNM stage. Furthermore, reduced PINK1 and PARK2 levels were associated with a poor prognosis for ESCC. Cox univariate and multivariate analyses revealed that PINK1, PARK2, and tumor size were closely associated with the prognosis of patients with ESCC, and PARK2 was an independent risk factor for patients with ESCC. Finally, the PINK1 and PARK2 proteins were closely related and shared the same signal pathway. CONCLUSIONS: PINK1 and PARK2 could work as tumor suppressors in ESCC and are likely to become new treatment targets for ESCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-03206-3. BioMed Central 2023-10-13 /pmc/articles/PMC10571472/ /pubmed/37833780 http://dx.doi.org/10.1186/s12957-023-03206-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lu, Xiangyun
Yao, Yongkun
Ma, Yandi
Zhang, Xudong
Peng, Hao
Pei, Yuhui
Lu, Yulin
Wang, Lianghai
Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma
title Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma
title_full Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma
title_fullStr Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma
title_full_unstemmed Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma
title_short Low expression of PINK1 and PARK2 predicts poor prognosis in patients with esophageal squamous cell carcinoma
title_sort low expression of pink1 and park2 predicts poor prognosis in patients with esophageal squamous cell carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571472/
https://www.ncbi.nlm.nih.gov/pubmed/37833780
http://dx.doi.org/10.1186/s12957-023-03206-3
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