Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer

ARID1A, an epigenetic tumor suppressor, is the most common gene mutation in clear-cell ovarian cancers (CCOCs). CCOCs are often resistant to standard chemotherapy and lack effective therapies. We hypothesized that ARID1A loss would increase CCOC cell dependency on chromatin remodeling and DNA repair...

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Detalles Bibliográficos
Autores principales: Kinose, Yasuto, Xu, Haineng, Kim, Hyoung, Kumar, Sushil, Shan, Xiaoyin, George, Erin, Wang, Xiaolei, Medvedev, Sergey, Ferman, Benjamin, Gitto, Sarah B., Whicker, Margaret, D’Andrea, Kurt, Wubbenhorst, Bradley, Hallberg, Dorothy, O’Connor, Mark, Schwartz, Lauren E., Hwang, Wei-Ting, Nathanson, Katherine L, Mills, Gordon B., Velculescu, Victor E., Wang, Tian-Li, Brown, Eric J., Drapkin, Ronny, Simpkins, Fiona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571599/
https://www.ncbi.nlm.nih.gov/pubmed/37841875
http://dx.doi.org/10.21203/rs.3.rs-3314138/v1

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