Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Senescent cells accumulate in organisms over time because of tissue damage and impaired immune surveillance and contribute to age-related tissue decline(1,2). In agreement, genetic ablation studies reveal that elimination of senescent cells from aged tissues can ameliorate various age-related pathol...

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Detalles Bibliográficos
Autores principales: Amor, Corina, Fernández-Maestre, Inés, Chowdhury, Saria, Ho, Yu-Jui, Nadella, Sandeep, Graham, Courtenay, Carrasco, Sebastian E., Nnuji-John, Emmanuella, Feucht, Judith, Hinterleitner, Clemens, Barthet, Valentin J.A., Boyer, Jacob A., Mezzadra, Riccardo, Wereski, Matthew G, Tuveson, David A., Levine, Ross L., Jones, Lee W, Sadelain, Michel, Lowe, Scott W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571605/
https://www.ncbi.nlm.nih.gov/pubmed/37841853
http://dx.doi.org/10.21203/rs.3.rs-3385749/v1

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