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SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer
SIMPLE SUMMARY: In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses within tumors. This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571764/ https://www.ncbi.nlm.nih.gov/pubmed/37835502 http://dx.doi.org/10.3390/cancers15194808 |
Sumario: | SIMPLE SUMMARY: In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses within tumors. This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impact on tumor progression in cancers like colorectal cancer and melanoma. Recent immunotherapy advances show promise, but challenges like resistance persist. Insights suggest that the SLAM family might be a key to overcoming this resistance. Advances in technology, including single-cell RNA sequencing, help to demystify tumor interactions, and SLAM-focused treatments could potentially revolutionize cancer care. This article underscores the importance of patient safety and calls for thorough research to bring the potential of SLAM in cancer treatment to fruition. ABSTRACT: In the field of oncology, the Signaling Lymphocyte Activation Molecule (SLAM) family is emerging as pivotal in modulating immune responses within tumor environments. The SLAM family comprises nine receptors, mainly found on immune cell surfaces. These receptors play complex roles in the interaction between cancer and the host immune system. Research suggests SLAM’s role in both enhancing and dampening tumor-immune responses, influencing the progression and treatment outcomes of various cancers. As immunotherapy advances, resistance remains an issue. The nuanced roles of the SLAM family might provide answers. With the rise in technologies like single-cell RNA sequencing and advanced imaging, there is potential for precise SLAM-targeted treatments. This review stresses patient safety, the importance of thorough clinical trials, and the potential of SLAM-focused therapies to transform cancer care. In summary, SLAM’s role in oncology signals a new direction for more tailored and adaptable cancer treatments. |
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