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SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer

SIMPLE SUMMARY: In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses within tumors. This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impac...

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Autores principales: Tojjari, Alireza, Giles, Francis J., Vilbert, Maysa, Saeed, Anwaar, Cavalcante, Ludimila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571764/
https://www.ncbi.nlm.nih.gov/pubmed/37835502
http://dx.doi.org/10.3390/cancers15194808
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author Tojjari, Alireza
Giles, Francis J.
Vilbert, Maysa
Saeed, Anwaar
Cavalcante, Ludimila
author_facet Tojjari, Alireza
Giles, Francis J.
Vilbert, Maysa
Saeed, Anwaar
Cavalcante, Ludimila
author_sort Tojjari, Alireza
collection PubMed
description SIMPLE SUMMARY: In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses within tumors. This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impact on tumor progression in cancers like colorectal cancer and melanoma. Recent immunotherapy advances show promise, but challenges like resistance persist. Insights suggest that the SLAM family might be a key to overcoming this resistance. Advances in technology, including single-cell RNA sequencing, help to demystify tumor interactions, and SLAM-focused treatments could potentially revolutionize cancer care. This article underscores the importance of patient safety and calls for thorough research to bring the potential of SLAM in cancer treatment to fruition. ABSTRACT: In the field of oncology, the Signaling Lymphocyte Activation Molecule (SLAM) family is emerging as pivotal in modulating immune responses within tumor environments. The SLAM family comprises nine receptors, mainly found on immune cell surfaces. These receptors play complex roles in the interaction between cancer and the host immune system. Research suggests SLAM’s role in both enhancing and dampening tumor-immune responses, influencing the progression and treatment outcomes of various cancers. As immunotherapy advances, resistance remains an issue. The nuanced roles of the SLAM family might provide answers. With the rise in technologies like single-cell RNA sequencing and advanced imaging, there is potential for precise SLAM-targeted treatments. This review stresses patient safety, the importance of thorough clinical trials, and the potential of SLAM-focused therapies to transform cancer care. In summary, SLAM’s role in oncology signals a new direction for more tailored and adaptable cancer treatments.
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spelling pubmed-105717642023-10-14 SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer Tojjari, Alireza Giles, Francis J. Vilbert, Maysa Saeed, Anwaar Cavalcante, Ludimila Cancers (Basel) Review SIMPLE SUMMARY: In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses within tumors. This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impact on tumor progression in cancers like colorectal cancer and melanoma. Recent immunotherapy advances show promise, but challenges like resistance persist. Insights suggest that the SLAM family might be a key to overcoming this resistance. Advances in technology, including single-cell RNA sequencing, help to demystify tumor interactions, and SLAM-focused treatments could potentially revolutionize cancer care. This article underscores the importance of patient safety and calls for thorough research to bring the potential of SLAM in cancer treatment to fruition. ABSTRACT: In the field of oncology, the Signaling Lymphocyte Activation Molecule (SLAM) family is emerging as pivotal in modulating immune responses within tumor environments. The SLAM family comprises nine receptors, mainly found on immune cell surfaces. These receptors play complex roles in the interaction between cancer and the host immune system. Research suggests SLAM’s role in both enhancing and dampening tumor-immune responses, influencing the progression and treatment outcomes of various cancers. As immunotherapy advances, resistance remains an issue. The nuanced roles of the SLAM family might provide answers. With the rise in technologies like single-cell RNA sequencing and advanced imaging, there is potential for precise SLAM-targeted treatments. This review stresses patient safety, the importance of thorough clinical trials, and the potential of SLAM-focused therapies to transform cancer care. In summary, SLAM’s role in oncology signals a new direction for more tailored and adaptable cancer treatments. MDPI 2023-09-29 /pmc/articles/PMC10571764/ /pubmed/37835502 http://dx.doi.org/10.3390/cancers15194808 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tojjari, Alireza
Giles, Francis J.
Vilbert, Maysa
Saeed, Anwaar
Cavalcante, Ludimila
SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer
title SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer
title_full SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer
title_fullStr SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer
title_full_unstemmed SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer
title_short SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer
title_sort slam modification as an immune-modulatory therapeutic approach in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571764/
https://www.ncbi.nlm.nih.gov/pubmed/37835502
http://dx.doi.org/10.3390/cancers15194808
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