Inhibition of O-GlcNAcylation Reduces Cell Viability and Autophagy and Increases Sensitivity to Chemotherapeutic Temozolomide in Glioblastoma

SIMPLE SUMMARY: Glioblastoma (GB) is the most common and aggressive type of malignant brain tumor; however, despite advances in treatment modalities, it remains largely incurable. Current therapeutic protocols are ineffective, and temozolomide (TMZ), the main chemotherapy used in GB treatment, has a...

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Detalles Bibliográficos
Autores principales: Leonel, Amanda V., Alisson-Silva, Frederico, Santos, Ronan C. M., Silva-Aguiar, Rodrigo P., Gomes, Julia C., Longo, Gabriel M. C., Faria, Bruna M., Siqueira, Mariana S., Pereira, Miria G., Vasconcelos-dos-Santos, Andreia, Chiarini, Luciana B., Slawson, Chad, Caruso-Neves, Celso, Romão, Luciana, Travassos, Leonardo H., Carneiro, Katia, Todeschini, Adriane R., Dias, Wagner B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571858/
https://www.ncbi.nlm.nih.gov/pubmed/37835434
http://dx.doi.org/10.3390/cancers15194740

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