Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720

This study provides evidence of the existence of presynaptic inhibitory sphingosine-1-phosphate receptor 1 (S1P1R) and facilitatory S1P3R in cortical nerve endings (synaptosomes) of healthy mice. The conclusion relies on the findings that (i) the S1P1R agonist CS-2100 (0.1–30 nM) inhibits the 12 mM...

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Detalles Bibliográficos
Autores principales: Roggeri, Alessandra, Olivero, Guendalina, Usai, Cesare, Vanmierlo, Tim, Pittaluga, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571862/
https://www.ncbi.nlm.nih.gov/pubmed/37830557
http://dx.doi.org/10.3390/cells12192343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571862/
https://www.ncbi.nlm.nih.gov/pubmed/37830557
http://dx.doi.org/10.3390/cells12192343

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