The Combined Inhibition of Autophagy and Diacylglycerol Acyltransferase-Mediated Lipid Droplet Biogenesis Induces Cancer Cell Death during Acute Amino Acid Starvation

SIMPLE SUMMARY: In this study, the relationship between autophagy and lipid droplets in the response of cancer cells to starvation was investigated. Under conditions of amino acid deprivation, autophagy was triggered and led to lipid droplet accumulation through diacylglycerol acyltransferase (DGAT)...

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Detalles Bibliográficos
Autores principales: Jusović, Maida, Starič, Pia, Jarc Jovičić, Eva, Petan, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571868/
https://www.ncbi.nlm.nih.gov/pubmed/37835551
http://dx.doi.org/10.3390/cancers15194857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571868/
https://www.ncbi.nlm.nih.gov/pubmed/37835551
http://dx.doi.org/10.3390/cancers15194857

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