Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling. Gliomas with increased ARL13B, SMO, and GLI2 expression are...

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Detalles Bibliográficos
Autores principales: Shi, Ping, Tian, Jia, Mallinger, Julianne C., Ling, Dahao, Deleyrolle, Loic P., McIntyre, Jeremy C., Caspary, Tamara, Breunig, Joshua J., Sarkisian, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571910/
https://www.ncbi.nlm.nih.gov/pubmed/37830570
http://dx.doi.org/10.3390/cells12192354

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