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Pro-Apoptotic Activity of MCL-1 Inhibitor in Trametinib-Resistant Melanoma Cells Depends on Their Phenotypes and Is Modulated by Reversible Alterations Induced by Trametinib Withdrawal
SIMPLE SUMMARY: Skin melanoma is fully curable by surgery if diagnosed at an early stage. Targeted drugs against BRAF(V600) and MEK1/2 were the first therapeutic breakthrough for patients with advanced melanoma. However, acquired drug resistance resulting in disease relapse interrupts the treatment...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571954/ https://www.ncbi.nlm.nih.gov/pubmed/37835493 http://dx.doi.org/10.3390/cancers15194799 |