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Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells

JZL184, an inhibitor of monoacylglycerol lipase (MAGL) and thus of the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG), mediates various anticancer effects in preclinical studies. However, studies on the effect of this or other MAGL inhibitors under hypoxia, an important factor in t...

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Detalles Bibliográficos
Autores principales: Wittig, Felix, Pannenberg, Liza, Schwarz, Rico, Bekeschus, Sander, Ramer, Robert, Hinz, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572003/
https://www.ncbi.nlm.nih.gov/pubmed/37830546
http://dx.doi.org/10.3390/cells12192332