Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

In this investigation, we tested the hypothesis that a physiologically based pharmacokinetic (PBPK) model incorporating measured in vitro metrics of off-target binding can largely explain the inter-antibody variability in monoclonal antibody (mAb) pharmacokinetics (PK). A diverse panel of 83 mAbs wa...

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Detalles Bibliográficos
Autores principales: Liu, Shufang, Humphreys, Sara C., Cook, Kevin D., Conner, Kip P., Correia, Ana R., Jacobitz, Alex W., Yang, Melissa, Primack, Ronya, Soto, Marcus, Padaki, Rupa, Lubomirski, Mariusz, Smith, Richard, Mock, Marissa, Thomas, Veena A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572049/
https://www.ncbi.nlm.nih.gov/pubmed/37824334
http://dx.doi.org/10.1080/19420862.2023.2263926

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