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Uncovering NOTCH1 as a Promising Target in the Treatment of MLL-Rearranged Leukemia

MLL rearrangement (MLLr) is responsible for the development of acute leukemias with poor outcomes. Therefore, new therapeutic approaches are urgently needed. The NOTCH1 pathway plays a critical role in the pathogenesis of many cancers including acute leukemia. Using a CRISPR/Cas9 MLL-AF4/-AF9 transl...

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Detalles Bibliográficos
Autores principales:	Fischer, Jacqueline, Erkner, Estelle, Fitzel, Rahel, Radszuweit, Pia, Keppeler, Hildegard, Korkmaz, Fulya, Roti, Giovanni, Lengerke, Claudia, Schneidawind, Dominik, Schneidawind, Corina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572120/ https://www.ncbi.nlm.nih.gov/pubmed/37833915 http://dx.doi.org/10.3390/ijms241914466

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