Cargando…

Sigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis

Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or heme and also several unrelated xenobiotics/chemicals. They reside in the plasma membrane and in the membranes of the endoplasmic reticulum, mitochondria, and nucleus. Until recently, the biology/pharmacology of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Nhi T., Jaramillo-Martinez, Valeria, Mathew, Marilyn, Suresh, Varshini V., Sivaprakasam, Sathish, Bhutia, Yangzom D., Ganapathy, Vadivel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572259/ https://www.ncbi.nlm.nih.gov/pubmed/37834119 http://dx.doi.org/10.3390/ijms241914672

Ejemplares similares

Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues
por: Mathew, Marilyn, et al.
Publicado: (2023)

Unconventional Functions of Amino Acid Transporters: Role in Macropinocytosis (SLC38A5/SLC38A3) and Diet-Induced Obesity/Metabolic Syndrome (SLC6A19/SLC6A14/SLC6A6)
por: Bhutia, Yangzom D., et al.
Publicado: (2022)

Potent Inhibition of Macropinocytosis by Niclosamide in Cancer Cells: A Novel Mechanism for the Anticancer Efficacy for the Antihelminthic
por: Sennoune, Souad R., et al.
Publicado: (2023)

Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health
por: Sivaprakasam, Sathish, et al.
Publicado: (2017)

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier
por: Kopel, Jonathan J., et al.
Publicado: (2021)

Binding of Citrate-Fe(3+) to Plastic Culture Dishes, an Artefact Useful as a Simple Technique to Screen for New Iron Chelators
por: Ogura, Jiro, et al.
Publicado: (2022)

SLC6A14, a Na(+)/Cl(−)-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling
por: Sikder, Mohd O. F., et al.
Publicado: (2020)

α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice
por: Sivaprakasam, Sathish, et al.
Publicado: (2021)

Drosophila INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions
por: Jaramillo-Martinez, Valeria, et al.
Publicado: (2021)

A Proton-Coupled Transport System for β-Hydroxy-β-Methylbutyrate (HMB) in Blood–Brain Barrier Endothelial Cell Line hCMEC/D3
por: Higuchi, Kei, et al.
Publicado: (2021)

Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2
por: Ristic, Bojana, et al.
Publicado: (2020)

Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine
por: Bhutia, Yangzom D., et al.
Publicado: (2016)

Expression and function of SLC38A5, an amino acid-coupled Na(+)/H(+) exchanger, in triple-negative breast cancer and its relevance to macropinocytosis
por: Ramachandran, Sabarish, et al.
Publicado: (2021)

SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer
por: Sniegowski, Tyler, et al.
Publicado: (2021)

Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer
por: Bhutia, Yangzom D., et al.
Publicado: (2020)

Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis
por: Ristic, Bojana, et al.
Publicado: (2020)

Functional analysis of a species-specific inhibitor selective for human Na(+)-coupled citrate transporter (NaCT/SLC13A5/mINDY)
por: Higuchi, Kei, et al.
Publicado: (2020)

Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types
por: Kou, Longfa, et al.
Publicado: (2018)

Plasma Membrane Na(+)-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy
por: Bhutia, Yangzom D., et al.
Publicado: (2017)

PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target
por: Schniers, Bradley K., et al.
Publicado: (2021)

RETRACTED ARTICLE: Identification of a novel Na(+)-coupled Fe(3+)-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells
por: Ogura, Jiro, et al.
Publicado: (2018)

Retraction Note: Identification of a novel Na(+)-coupled Fe(3+)-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells
por: Ogura, Jiro, et al.
Publicado: (2018)

Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery
por: Kou, Longfa, et al.
Publicado: (2020)

Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis
por: Lv, Peng, et al.
Publicado: (2023)

Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu
por: Sivaprakasam, Sathish, et al.
Publicado: (2019)

A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects
por: Jaramillo-Martinez, Valeria, et al.
Publicado: (2021)

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer
por: Schniers, Bradley K., et al.
Publicado: (2022)

Iron homeostasis imbalance and ferroptosis in brain diseases
por: Long, Haining, et al.
Publicado: (2023)

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells
por: Consoli, Valeria, et al.
Publicado: (2022)

Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB(0,+) to deliver chemotherapeutic agents for colon cancer therapy
por: Kou, Longfa, et al.
Publicado: (2017)

Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity
por: Romeo, Giuseppe, et al.
Publicado: (2021)

Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis
por: Gnana-Prakasam, Jaya P., et al.
Publicado: (2014)

The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
por: Huo, Caiyun, et al.
Publicado: (2022)

Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1
por: Ha, Yonju, et al.
Publicado: (2012)

Heme Oxygenase Activity Correlates with Serum Indices of Iron Homeostasis in Healthy Nonsmokers
por: Ghio, Andrew J., et al.
Publicado: (2016)

Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma
por: Yao, Fengping, et al.
Publicado: (2021)

Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency
por: Kartikasari, Apriliana E R, et al.
Publicado: (2010)

Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency
por: Kartikasari, Apriliana E R, et al.
Publicado: (2009)

GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis
por: Wang, Lingjuan, et al.
Publicado: (2021)

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
por: Consoli, Valeria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_aqtqpeil4ahi4cpvut8lvr4t9o