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Role of Semaphorin 3A in Kidney Development and Diseases

Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell...

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Autores principales: Sang, Yizhen, Tsuji, Kenji, Nakanoh, Hiroyuki, Fukushima, Kazuhiko, Kitamura, Shinji, Wada, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572269/
https://www.ncbi.nlm.nih.gov/pubmed/37835781
http://dx.doi.org/10.3390/diagnostics13193038
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author Sang, Yizhen
Tsuji, Kenji
Nakanoh, Hiroyuki
Fukushima, Kazuhiko
Kitamura, Shinji
Wada, Jun
author_facet Sang, Yizhen
Tsuji, Kenji
Nakanoh, Hiroyuki
Fukushima, Kazuhiko
Kitamura, Shinji
Wada, Jun
author_sort Sang, Yizhen
collection PubMed
description Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving in the several pathogeneses of diseases, including eyes and neurons, as well as kidneys. SEMA3A is expressed in podocytes and tubular cells in the normal adult kidney, and recent evidence has revealed that excess SEMA3A expression and the subsequent signaling pathway aggravate kidney injury in a variety of kidney diseases, including nephrotic syndrome, diabetic nephropathy, acute kidney injury, and chronic kidney disease. In addition, several reports have demonstrated that the inhibition of SEMA3A ameliorated kidney injury via a reduction in cell apoptosis, fibrosis and inflammation; thus, SEMA3A may be a potential therapeutic target for kidney diseases. In this review article, we summarized the current knowledge regarding the role of SEMA3A in kidney pathophysiology and their potential use in kidney diseases.
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spelling pubmed-105722692023-10-14 Role of Semaphorin 3A in Kidney Development and Diseases Sang, Yizhen Tsuji, Kenji Nakanoh, Hiroyuki Fukushima, Kazuhiko Kitamura, Shinji Wada, Jun Diagnostics (Basel) Review Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving in the several pathogeneses of diseases, including eyes and neurons, as well as kidneys. SEMA3A is expressed in podocytes and tubular cells in the normal adult kidney, and recent evidence has revealed that excess SEMA3A expression and the subsequent signaling pathway aggravate kidney injury in a variety of kidney diseases, including nephrotic syndrome, diabetic nephropathy, acute kidney injury, and chronic kidney disease. In addition, several reports have demonstrated that the inhibition of SEMA3A ameliorated kidney injury via a reduction in cell apoptosis, fibrosis and inflammation; thus, SEMA3A may be a potential therapeutic target for kidney diseases. In this review article, we summarized the current knowledge regarding the role of SEMA3A in kidney pathophysiology and their potential use in kidney diseases. MDPI 2023-09-25 /pmc/articles/PMC10572269/ /pubmed/37835781 http://dx.doi.org/10.3390/diagnostics13193038 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sang, Yizhen
Tsuji, Kenji
Nakanoh, Hiroyuki
Fukushima, Kazuhiko
Kitamura, Shinji
Wada, Jun
Role of Semaphorin 3A in Kidney Development and Diseases
title Role of Semaphorin 3A in Kidney Development and Diseases
title_full Role of Semaphorin 3A in Kidney Development and Diseases
title_fullStr Role of Semaphorin 3A in Kidney Development and Diseases
title_full_unstemmed Role of Semaphorin 3A in Kidney Development and Diseases
title_short Role of Semaphorin 3A in Kidney Development and Diseases
title_sort role of semaphorin 3a in kidney development and diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572269/
https://www.ncbi.nlm.nih.gov/pubmed/37835781
http://dx.doi.org/10.3390/diagnostics13193038
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