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Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer

Objective: To investigate the correlation between total protein expression of heart development protein with EGF-like domain 1 (HEG1) and clinicopathological characteristics in patients with bladder cancer (BC) after radical cystectomy (RC). Patients and Methods: We retrospectively analyzed data fro...

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Autores principales: Mori, Kohei, Matsumoto, Kazumasa, Ikeda, Masaomi, Koguchi, Dai, Shimizu, Yuriko, Tsumura, Hideyasu, Ishii, Daisuke, Tsuji, Shoutaro, Sato, Yuichi, Iwamura, Masatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572329/
https://www.ncbi.nlm.nih.gov/pubmed/37835810
http://dx.doi.org/10.3390/diagnostics13193067
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author Mori, Kohei
Matsumoto, Kazumasa
Ikeda, Masaomi
Koguchi, Dai
Shimizu, Yuriko
Tsumura, Hideyasu
Ishii, Daisuke
Tsuji, Shoutaro
Sato, Yuichi
Iwamura, Masatsugu
author_facet Mori, Kohei
Matsumoto, Kazumasa
Ikeda, Masaomi
Koguchi, Dai
Shimizu, Yuriko
Tsumura, Hideyasu
Ishii, Daisuke
Tsuji, Shoutaro
Sato, Yuichi
Iwamura, Masatsugu
author_sort Mori, Kohei
collection PubMed
description Objective: To investigate the correlation between total protein expression of heart development protein with EGF-like domain 1 (HEG1) and clinicopathological characteristics in patients with bladder cancer (BC) after radical cystectomy (RC). Patients and Methods: We retrospectively analyzed data from 110 patients who underwent RC at Kitasato University Hospital. And we prepared an anti-HEG1 monoclonal antibody W10B9, which can detect total HEG1 protein. HEG1 protein expression in tumor cells was evaluated separately for membrane and cytoplasmic staining using immunohistochemistry. Results: Membranous HEG1 expression was associated with absent lymphovascular invasion (p < 0.01) and low pT stage (p < 0.01). Kaplan–Meier analysis revealed that the membranous HEG1-positive group had significantly long recurrence-free survival (RFS) (p < 0.01) and cancer-specific survival (p = 0.01). Expression of membranous HEG1 was identified as an independent prognostic factor for RFS (p = 0.04). There were no significant differences between cytoplasmic HEG1 expression and clinicopathologic factors including prognosis. Conclusion: The expression of membranous HEG1 could serve as a favorable prognostic indicator in patients with BC treated with RC.
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spelling pubmed-105723292023-10-14 Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer Mori, Kohei Matsumoto, Kazumasa Ikeda, Masaomi Koguchi, Dai Shimizu, Yuriko Tsumura, Hideyasu Ishii, Daisuke Tsuji, Shoutaro Sato, Yuichi Iwamura, Masatsugu Diagnostics (Basel) Article Objective: To investigate the correlation between total protein expression of heart development protein with EGF-like domain 1 (HEG1) and clinicopathological characteristics in patients with bladder cancer (BC) after radical cystectomy (RC). Patients and Methods: We retrospectively analyzed data from 110 patients who underwent RC at Kitasato University Hospital. And we prepared an anti-HEG1 monoclonal antibody W10B9, which can detect total HEG1 protein. HEG1 protein expression in tumor cells was evaluated separately for membrane and cytoplasmic staining using immunohistochemistry. Results: Membranous HEG1 expression was associated with absent lymphovascular invasion (p < 0.01) and low pT stage (p < 0.01). Kaplan–Meier analysis revealed that the membranous HEG1-positive group had significantly long recurrence-free survival (RFS) (p < 0.01) and cancer-specific survival (p = 0.01). Expression of membranous HEG1 was identified as an independent prognostic factor for RFS (p = 0.04). There were no significant differences between cytoplasmic HEG1 expression and clinicopathologic factors including prognosis. Conclusion: The expression of membranous HEG1 could serve as a favorable prognostic indicator in patients with BC treated with RC. MDPI 2023-09-27 /pmc/articles/PMC10572329/ /pubmed/37835810 http://dx.doi.org/10.3390/diagnostics13193067 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mori, Kohei
Matsumoto, Kazumasa
Ikeda, Masaomi
Koguchi, Dai
Shimizu, Yuriko
Tsumura, Hideyasu
Ishii, Daisuke
Tsuji, Shoutaro
Sato, Yuichi
Iwamura, Masatsugu
Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer
title Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer
title_full Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer
title_fullStr Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer
title_full_unstemmed Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer
title_short Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer
title_sort membranous expression of heart development protein with egf-like domain 1 is associated with a good prognosis in patients with bladder cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572329/
https://www.ncbi.nlm.nih.gov/pubmed/37835810
http://dx.doi.org/10.3390/diagnostics13193067
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