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EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications
Epileptogenesis is characterized by intrinsic changes in neuronal firing, resulting in hyperactive neurons and the subsequent generation of seizure activity. These alterations are accompanied by changes in gene transcription networks, first with the activation of early-immediate genes and later with...
Autores principales: | Burke, Cassidy T., Vitko, Iuliia, Straub, Justyna, Nylund, Elsa O., Gawda, Agnieszka, Blair, Kathryn, Sullivan, Kyle A., Ergun, Lara, Ottolini, Matteo, Patel, Manoj K., Perez-Reyes, Edward |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572392/ https://www.ncbi.nlm.nih.gov/pubmed/37833914 http://dx.doi.org/10.3390/ijms241914467 |
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