Cargando…

ETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2α/ATF4 Signaling

Triple-negative breast cancer (TNBC) is the most fatal subtype of breast cancer; however, effective treatment strategies for TNBC are lacking. Therefore, it is important to explore the mechanism of TNBC metastasis and identify its therapeutic targets. Dysregulation of ETHE1 leads to ethylmalonic enc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Shao-Ying, Liao, Li, Hu, Shu-Yuan, Deng, Ling, Andriani, Lisa, Zhang, Tai-Mei, Zhang, Yin-Ling, Ma, Xiao-Yan, Zhang, Fang-Lin, Liu, Ying-Ying, Li, Da-Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572406/ https://www.ncbi.nlm.nih.gov/pubmed/37834012 http://dx.doi.org/10.3390/ijms241914566

Ejemplares similares

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway
por: Chen, Meng-Shian, et al.
Publicado: (2017)

Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis
por: Bai, Xupeng, et al.
Publicado: (2021)

Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway
por: Carraro, Valérie, et al.
Publicado: (2010)

Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK
por: Anderson, Bart R., et al.
Publicado: (2012)

Involvement of the eIF2α Kinase GCN2 in UV-B Responses
por: Llabata, Paula, et al.
Publicado: (2019)

Modulation of GCN2/eIF2α/ATF4 Pathway in the Liver and Induction of FGF21 in Young Goats Fed a Protein- and/or Phosphorus-Reduced Diet
por: Weber, Sarah L., et al.
Publicado: (2023)

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway
por: Wang, Sheng-Fan, et al.
Publicado: (2016)

Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation-Dependent Cellular Translation Shutoff via PERK/GCN2
por: Liu, Yuanzhi, et al.
Publicado: (2021)

Endoplasmic reticulum stress inhibits AR expression via the PERK/eIF2α/ATF4 pathway in luminal androgen receptor triple-negative breast cancer and prostate cancer
por: Li, Xiaoli, et al.
Publicado: (2022)

C9orf142 transcriptionally activates MTBP to drive progression and resistance to CDK4/6 inhibitor in triple‐negative breast cancer
por: Liao, Li, et al.
Publicado: (2023)

Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
por: Yuan, Feixiang, et al.
Publicado: (2020)

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
por: Cordova, Ricardo A, et al.
Publicado: (2022)

ERH Interacts With EIF2α and Regulates the EIF2α/ATF4/CHOP Pathway in Bladder Cancer Cells
por: Pang, Kun, et al.
Publicado: (2022)

Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation
por: Li, Yueyang, et al.
Publicado: (2020)

4E-BP is a target of the GCN2–ATF4 pathway during Drosophila development and aging
por: Kang, Min-Ji, et al.
Publicado: (2017)

Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival
por: Alasiri, Glowi, et al.
Publicado: (2020)

Arabidopsis eIF2α kinase GCN2 is essential for growth in stress conditions and is activated by wounding
por: Lageix, Sébastien, et al.
Publicado: (2008)

Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
por: Zaborske, John M, et al.
Publicado: (2010)

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2
por: Baker, Brooke M., et al.
Publicado: (2012)

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
por: Misra, Jagannath, et al.
Publicado: (2021)

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway
por: Sun, Jing, et al.
Publicado: (2021)

N-{2-[4-(2-Hydroxyethyl)piperazin-1-yl]ethyl}phthalimide
por: Shao, Ying, et al.
Publicado: (2011)

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway
por: Chaveroux, Cédric, et al.
Publicado: (2016)

HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2
por: Peidis, Philippos, et al.
Publicado: (2010)

Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease
por: Devi, Latha, et al.
Publicado: (2013)

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii
por: Augusto, Leonardo, et al.
Publicado: (2019)

Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2α pathway
por: Romero, Antonia María, et al.
Publicado: (2020)

The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity
por: Stonyte, Vilte, et al.
Publicado: (2023)

Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer
por: Liao, Li, et al.
Publicado: (2023)

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
por: Averous, Julien, et al.
Publicado: (2016)

Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis
por: Jin, Hyeon-Ok, et al.
Publicado: (2021)

INCREASED LIFESPAN THROUGH ALTERED GCN4 / ATF-5 IN S. CEREVISIAE AND C. ELEGANS
por: McCormick, Mark, et al.
Publicado: (2019)

Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells
por: Lageix, Sebastien, et al.
Publicado: (2014)

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis
por: Dias-Teixeira, Karina Luiza, et al.
Publicado: (2017)

HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection
por: Jiang, Guochun, et al.
Publicado: (2017)

Bis({1-[(1-iminoethyl)imino]ethyl}azanido-κ(2) N (1),N (5))nickel(II) methanol monosolvate
por: Xie, Yong-Qiang, et al.
Publicado: (2012)

2-(2-Bromoethyl)isoindoline-1,3-dione
por: Sun, Xiao-Qiang, et al.
Publicado: (2011)

Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program
por: Srinivasan, Rajalakshmi, et al.
Publicado: (2020)

(E)-2,4-Dichloro-6-{1-[(2-chloroethyl)imino]ethyl}phenol
por: Xie, Yong-Sheng, et al.
Publicado: (2010)

Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats
por: Rong, Ke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tlh5i3nblq3k36udi092112c6s