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Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic tra...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572431/ https://www.ncbi.nlm.nih.gov/pubmed/37834155 http://dx.doi.org/10.3390/ijms241914709 |
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author | Kolotyeva, Nataliya A. Gilmiyarova, Frida N. Averchuk, Anton S. Baranich, Tatiana I. Rozanova, Nataliya A. Kukla, Maria V. Tregub, Pavel P. Salmina, Alla B. |
author_facet | Kolotyeva, Nataliya A. Gilmiyarova, Frida N. Averchuk, Anton S. Baranich, Tatiana I. Rozanova, Nataliya A. Kukla, Maria V. Tregub, Pavel P. Salmina, Alla B. |
author_sort | Kolotyeva, Nataliya A. |
collection | PubMed |
description | The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission and remodeling, neurogenesis and angiogenesis, and changes in the metabolism associated with the establishment of new intercellular connections. Therefore, the extracellular scaffolds that are helpful in the establishment and maintenance of local microenvironments supporting brain plasticity mechanisms are of critical importance. In this review, we will focus on some carbohydrate metabolites—lactate, pyruvate, oxaloacetate, malate—that greatly contribute to the regulation of cell-to-cell communications and metabolic plasticity of brain cells and on some resorbable biopolymers that may reproduce the local microenvironment enriched in particular cell metabolites. |
format | Online Article Text |
id | pubmed-10572431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105724312023-10-14 Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models Kolotyeva, Nataliya A. Gilmiyarova, Frida N. Averchuk, Anton S. Baranich, Tatiana I. Rozanova, Nataliya A. Kukla, Maria V. Tregub, Pavel P. Salmina, Alla B. Int J Mol Sci Review The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission and remodeling, neurogenesis and angiogenesis, and changes in the metabolism associated with the establishment of new intercellular connections. Therefore, the extracellular scaffolds that are helpful in the establishment and maintenance of local microenvironments supporting brain plasticity mechanisms are of critical importance. In this review, we will focus on some carbohydrate metabolites—lactate, pyruvate, oxaloacetate, malate—that greatly contribute to the regulation of cell-to-cell communications and metabolic plasticity of brain cells and on some resorbable biopolymers that may reproduce the local microenvironment enriched in particular cell metabolites. MDPI 2023-09-28 /pmc/articles/PMC10572431/ /pubmed/37834155 http://dx.doi.org/10.3390/ijms241914709 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kolotyeva, Nataliya A. Gilmiyarova, Frida N. Averchuk, Anton S. Baranich, Tatiana I. Rozanova, Nataliya A. Kukla, Maria V. Tregub, Pavel P. Salmina, Alla B. Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models |
title | Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models |
title_full | Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models |
title_fullStr | Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models |
title_full_unstemmed | Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models |
title_short | Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models |
title_sort | novel approaches to the establishment of local microenvironment from resorbable biomaterials in the brain in vitro models |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572431/ https://www.ncbi.nlm.nih.gov/pubmed/37834155 http://dx.doi.org/10.3390/ijms241914709 |
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