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Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models

The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic tra...

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Autores principales: Kolotyeva, Nataliya A., Gilmiyarova, Frida N., Averchuk, Anton S., Baranich, Tatiana I., Rozanova, Nataliya A., Kukla, Maria V., Tregub, Pavel P., Salmina, Alla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572431/
https://www.ncbi.nlm.nih.gov/pubmed/37834155
http://dx.doi.org/10.3390/ijms241914709
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author Kolotyeva, Nataliya A.
Gilmiyarova, Frida N.
Averchuk, Anton S.
Baranich, Tatiana I.
Rozanova, Nataliya A.
Kukla, Maria V.
Tregub, Pavel P.
Salmina, Alla B.
author_facet Kolotyeva, Nataliya A.
Gilmiyarova, Frida N.
Averchuk, Anton S.
Baranich, Tatiana I.
Rozanova, Nataliya A.
Kukla, Maria V.
Tregub, Pavel P.
Salmina, Alla B.
author_sort Kolotyeva, Nataliya A.
collection PubMed
description The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission and remodeling, neurogenesis and angiogenesis, and changes in the metabolism associated with the establishment of new intercellular connections. Therefore, the extracellular scaffolds that are helpful in the establishment and maintenance of local microenvironments supporting brain plasticity mechanisms are of critical importance. In this review, we will focus on some carbohydrate metabolites—lactate, pyruvate, oxaloacetate, malate—that greatly contribute to the regulation of cell-to-cell communications and metabolic plasticity of brain cells and on some resorbable biopolymers that may reproduce the local microenvironment enriched in particular cell metabolites.
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spelling pubmed-105724312023-10-14 Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models Kolotyeva, Nataliya A. Gilmiyarova, Frida N. Averchuk, Anton S. Baranich, Tatiana I. Rozanova, Nataliya A. Kukla, Maria V. Tregub, Pavel P. Salmina, Alla B. Int J Mol Sci Review The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission and remodeling, neurogenesis and angiogenesis, and changes in the metabolism associated with the establishment of new intercellular connections. Therefore, the extracellular scaffolds that are helpful in the establishment and maintenance of local microenvironments supporting brain plasticity mechanisms are of critical importance. In this review, we will focus on some carbohydrate metabolites—lactate, pyruvate, oxaloacetate, malate—that greatly contribute to the regulation of cell-to-cell communications and metabolic plasticity of brain cells and on some resorbable biopolymers that may reproduce the local microenvironment enriched in particular cell metabolites. MDPI 2023-09-28 /pmc/articles/PMC10572431/ /pubmed/37834155 http://dx.doi.org/10.3390/ijms241914709 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kolotyeva, Nataliya A.
Gilmiyarova, Frida N.
Averchuk, Anton S.
Baranich, Tatiana I.
Rozanova, Nataliya A.
Kukla, Maria V.
Tregub, Pavel P.
Salmina, Alla B.
Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
title Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
title_full Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
title_fullStr Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
title_full_unstemmed Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
title_short Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
title_sort novel approaches to the establishment of local microenvironment from resorbable biomaterials in the brain in vitro models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572431/
https://www.ncbi.nlm.nih.gov/pubmed/37834155
http://dx.doi.org/10.3390/ijms241914709
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