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Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One ther...

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Autores principales: Schimmel, Samantha, El Sayed, Bassel, Lockard, Gavin, Gordon, Jonah, Young, Isabella, D’Egidio, Francesco, Lee, Jea Young, Rodriguez, Thomas, Borlongan, Cesar V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572450/
https://www.ncbi.nlm.nih.gov/pubmed/37834059
http://dx.doi.org/10.3390/ijms241914612
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author Schimmel, Samantha
El Sayed, Bassel
Lockard, Gavin
Gordon, Jonah
Young, Isabella
D’Egidio, Francesco
Lee, Jea Young
Rodriguez, Thomas
Borlongan, Cesar V.
author_facet Schimmel, Samantha
El Sayed, Bassel
Lockard, Gavin
Gordon, Jonah
Young, Isabella
D’Egidio, Francesco
Lee, Jea Young
Rodriguez, Thomas
Borlongan, Cesar V.
author_sort Schimmel, Samantha
collection PubMed
description Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One therapeutic intervention being increasingly explored for TBI is hyperbaric oxygen therapy (HBOT), which is already approved clinically for treating open wounds. HBOT consists of 100% oxygen administration, usually between 1.5 and 3 atm and has been found to increase brain oxygenation levels after hypoxia in addition to decreasing levels of inflammation, apoptosis, intracranial pressure, and edema, reducing subsequent secondary injury. The following review examines recent preclinical and clinical studies on HBOT in the context of TBI with a focus on contributing mechanisms and clinical potential. Several preclinical studies have identified pathways, such as TLR4/NF-kB, that are affected by HBOT and contribute to its therapeutic effect. Thus far, the mechanisms mediating HBOT treatment have yet to be fully elucidated and are of interest to researchers. Nonetheless, multiple clinical studies presented in this review have examined the safety of HBOT and demonstrated the improved neurological function of TBI patients after HBOT, deeming it a promising avenue for treatment.
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spelling pubmed-105724502023-10-14 Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy Schimmel, Samantha El Sayed, Bassel Lockard, Gavin Gordon, Jonah Young, Isabella D’Egidio, Francesco Lee, Jea Young Rodriguez, Thomas Borlongan, Cesar V. Int J Mol Sci Review Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One therapeutic intervention being increasingly explored for TBI is hyperbaric oxygen therapy (HBOT), which is already approved clinically for treating open wounds. HBOT consists of 100% oxygen administration, usually between 1.5 and 3 atm and has been found to increase brain oxygenation levels after hypoxia in addition to decreasing levels of inflammation, apoptosis, intracranial pressure, and edema, reducing subsequent secondary injury. The following review examines recent preclinical and clinical studies on HBOT in the context of TBI with a focus on contributing mechanisms and clinical potential. Several preclinical studies have identified pathways, such as TLR4/NF-kB, that are affected by HBOT and contribute to its therapeutic effect. Thus far, the mechanisms mediating HBOT treatment have yet to be fully elucidated and are of interest to researchers. Nonetheless, multiple clinical studies presented in this review have examined the safety of HBOT and demonstrated the improved neurological function of TBI patients after HBOT, deeming it a promising avenue for treatment. MDPI 2023-09-27 /pmc/articles/PMC10572450/ /pubmed/37834059 http://dx.doi.org/10.3390/ijms241914612 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schimmel, Samantha
El Sayed, Bassel
Lockard, Gavin
Gordon, Jonah
Young, Isabella
D’Egidio, Francesco
Lee, Jea Young
Rodriguez, Thomas
Borlongan, Cesar V.
Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy
title Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy
title_full Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy
title_fullStr Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy
title_full_unstemmed Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy
title_short Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy
title_sort identifying the target traumatic brain injury population for hyperbaric oxygen therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572450/
https://www.ncbi.nlm.nih.gov/pubmed/37834059
http://dx.doi.org/10.3390/ijms241914612
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