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Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy
Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One ther...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572450/ https://www.ncbi.nlm.nih.gov/pubmed/37834059 http://dx.doi.org/10.3390/ijms241914612 |
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author | Schimmel, Samantha El Sayed, Bassel Lockard, Gavin Gordon, Jonah Young, Isabella D’Egidio, Francesco Lee, Jea Young Rodriguez, Thomas Borlongan, Cesar V. |
author_facet | Schimmel, Samantha El Sayed, Bassel Lockard, Gavin Gordon, Jonah Young, Isabella D’Egidio, Francesco Lee, Jea Young Rodriguez, Thomas Borlongan, Cesar V. |
author_sort | Schimmel, Samantha |
collection | PubMed |
description | Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One therapeutic intervention being increasingly explored for TBI is hyperbaric oxygen therapy (HBOT), which is already approved clinically for treating open wounds. HBOT consists of 100% oxygen administration, usually between 1.5 and 3 atm and has been found to increase brain oxygenation levels after hypoxia in addition to decreasing levels of inflammation, apoptosis, intracranial pressure, and edema, reducing subsequent secondary injury. The following review examines recent preclinical and clinical studies on HBOT in the context of TBI with a focus on contributing mechanisms and clinical potential. Several preclinical studies have identified pathways, such as TLR4/NF-kB, that are affected by HBOT and contribute to its therapeutic effect. Thus far, the mechanisms mediating HBOT treatment have yet to be fully elucidated and are of interest to researchers. Nonetheless, multiple clinical studies presented in this review have examined the safety of HBOT and demonstrated the improved neurological function of TBI patients after HBOT, deeming it a promising avenue for treatment. |
format | Online Article Text |
id | pubmed-10572450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105724502023-10-14 Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy Schimmel, Samantha El Sayed, Bassel Lockard, Gavin Gordon, Jonah Young, Isabella D’Egidio, Francesco Lee, Jea Young Rodriguez, Thomas Borlongan, Cesar V. Int J Mol Sci Review Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One therapeutic intervention being increasingly explored for TBI is hyperbaric oxygen therapy (HBOT), which is already approved clinically for treating open wounds. HBOT consists of 100% oxygen administration, usually between 1.5 and 3 atm and has been found to increase brain oxygenation levels after hypoxia in addition to decreasing levels of inflammation, apoptosis, intracranial pressure, and edema, reducing subsequent secondary injury. The following review examines recent preclinical and clinical studies on HBOT in the context of TBI with a focus on contributing mechanisms and clinical potential. Several preclinical studies have identified pathways, such as TLR4/NF-kB, that are affected by HBOT and contribute to its therapeutic effect. Thus far, the mechanisms mediating HBOT treatment have yet to be fully elucidated and are of interest to researchers. Nonetheless, multiple clinical studies presented in this review have examined the safety of HBOT and demonstrated the improved neurological function of TBI patients after HBOT, deeming it a promising avenue for treatment. MDPI 2023-09-27 /pmc/articles/PMC10572450/ /pubmed/37834059 http://dx.doi.org/10.3390/ijms241914612 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schimmel, Samantha El Sayed, Bassel Lockard, Gavin Gordon, Jonah Young, Isabella D’Egidio, Francesco Lee, Jea Young Rodriguez, Thomas Borlongan, Cesar V. Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy |
title | Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy |
title_full | Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy |
title_fullStr | Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy |
title_full_unstemmed | Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy |
title_short | Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy |
title_sort | identifying the target traumatic brain injury population for hyperbaric oxygen therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572450/ https://www.ncbi.nlm.nih.gov/pubmed/37834059 http://dx.doi.org/10.3390/ijms241914612 |
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