Hyperinsulinemia Impairs Clathrin-Mediated Endocytosis of the Insulin Receptor and Activation of Endothelial Nitric Oxide Synthase in Brain Endothelial Cells

Adequate perfusion of cerebral tissues, which is necessary for the preservation of optimal brain health, depends on insulin signaling within brain endothelial cells. Proper insulin signaling relies on the regulated internalization of insulin bound to the insulin receptor, a process which is disrupte...

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Detalles Bibliográficos
Autores principales: DiLucia, Stephanie G., Kendrick, B. Jacob, Sims-Robinson, Catrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572607/
https://www.ncbi.nlm.nih.gov/pubmed/37834116
http://dx.doi.org/10.3390/ijms241914670

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