Cargando…

FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma

This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better prediction. In total, 100 patients diagnosed with ESCC,...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yung-Cheng, Chiu, Nan-Tsing, Lu, Hung-I, Chiu, Yi-Chun, Hsu, Chien-Chin, Wang, Yu-Ming, Li, Shau-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572619/
https://www.ncbi.nlm.nih.gov/pubmed/37835827
http://dx.doi.org/10.3390/diagnostics13193083
_version_ 1785120275587661824
author Huang, Yung-Cheng
Chiu, Nan-Tsing
Lu, Hung-I
Chiu, Yi-Chun
Hsu, Chien-Chin
Wang, Yu-Ming
Li, Shau-Hsuan
author_facet Huang, Yung-Cheng
Chiu, Nan-Tsing
Lu, Hung-I
Chiu, Yi-Chun
Hsu, Chien-Chin
Wang, Yu-Ming
Li, Shau-Hsuan
author_sort Huang, Yung-Cheng
collection PubMed
description This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better prediction. In total, 100 patients diagnosed with ESCC, 57 without (CRT([−]sub)) and 43 with (CRT([+]sub)) neoadjuvant chemoradiotherapy, undergoing EUS and FDG PET/CT, followed by surgical resection of the tumor, were included in this analysis. EUS classified T-stages based on the depth of primary tumor invasion, and FDG PET/CT used thresholded maximal standardized uptake value (SUV(max)) classifications. By employing pathology results as the reference standard, we assessed the accuracy of EUS and FDG PET/CT, evaluated their concordance using the κ statistic, and conducted a comparative analysis between the two modalities through McNemar’s chi-square test. FDG PET/CT had higher overall accuracy than EUS (for CRT([−]sub): 71.9%, κ = 0.56 vs. 56.1%, κ = 0.31, p = 0.06; for CRT([+]sub): 65.1%, κ = 0.50 vs. 18.6%, κ = 0.05, p < 0.01) in predicting pT- and ypT-stage. Our proposed method of incorporating both FDG PET/CT and EUS information could achieve higher accuracies in differentiating between early and locally advanced disease in the CRT([−]sub) group (82.5%) and determining residual viable tumor in the CRT([+]sub) group (83.7%) than FDG PET/CT or EUS alone. FDG PET/CT had a better diagnostic ability than EUS to predict the (y)pT-stage of ESCC. Our complementary method, which combines the advantages of both imaging modalities, can deliver higher accuracy for clinical applications of ESCC.
format Online
Article
Text
id pubmed-10572619
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105726192023-10-14 FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma Huang, Yung-Cheng Chiu, Nan-Tsing Lu, Hung-I Chiu, Yi-Chun Hsu, Chien-Chin Wang, Yu-Ming Li, Shau-Hsuan Diagnostics (Basel) Article This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better prediction. In total, 100 patients diagnosed with ESCC, 57 without (CRT([−]sub)) and 43 with (CRT([+]sub)) neoadjuvant chemoradiotherapy, undergoing EUS and FDG PET/CT, followed by surgical resection of the tumor, were included in this analysis. EUS classified T-stages based on the depth of primary tumor invasion, and FDG PET/CT used thresholded maximal standardized uptake value (SUV(max)) classifications. By employing pathology results as the reference standard, we assessed the accuracy of EUS and FDG PET/CT, evaluated their concordance using the κ statistic, and conducted a comparative analysis between the two modalities through McNemar’s chi-square test. FDG PET/CT had higher overall accuracy than EUS (for CRT([−]sub): 71.9%, κ = 0.56 vs. 56.1%, κ = 0.31, p = 0.06; for CRT([+]sub): 65.1%, κ = 0.50 vs. 18.6%, κ = 0.05, p < 0.01) in predicting pT- and ypT-stage. Our proposed method of incorporating both FDG PET/CT and EUS information could achieve higher accuracies in differentiating between early and locally advanced disease in the CRT([−]sub) group (82.5%) and determining residual viable tumor in the CRT([+]sub) group (83.7%) than FDG PET/CT or EUS alone. FDG PET/CT had a better diagnostic ability than EUS to predict the (y)pT-stage of ESCC. Our complementary method, which combines the advantages of both imaging modalities, can deliver higher accuracy for clinical applications of ESCC. MDPI 2023-09-28 /pmc/articles/PMC10572619/ /pubmed/37835827 http://dx.doi.org/10.3390/diagnostics13193083 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Yung-Cheng
Chiu, Nan-Tsing
Lu, Hung-I
Chiu, Yi-Chun
Hsu, Chien-Chin
Wang, Yu-Ming
Li, Shau-Hsuan
FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma
title FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma
title_full FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma
title_fullStr FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma
title_full_unstemmed FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma
title_short FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma
title_sort fdg pet/ct and endoscopic ultrasound for preoperative t-staging of esophageal squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572619/
https://www.ncbi.nlm.nih.gov/pubmed/37835827
http://dx.doi.org/10.3390/diagnostics13193083
work_keys_str_mv AT huangyungcheng fdgpetctandendoscopicultrasoundforpreoperativetstagingofesophagealsquamouscellcarcinoma
AT chiunantsing fdgpetctandendoscopicultrasoundforpreoperativetstagingofesophagealsquamouscellcarcinoma
AT luhungi fdgpetctandendoscopicultrasoundforpreoperativetstagingofesophagealsquamouscellcarcinoma
AT chiuyichun fdgpetctandendoscopicultrasoundforpreoperativetstagingofesophagealsquamouscellcarcinoma
AT hsuchienchin fdgpetctandendoscopicultrasoundforpreoperativetstagingofesophagealsquamouscellcarcinoma
AT wangyuming fdgpetctandendoscopicultrasoundforpreoperativetstagingofesophagealsquamouscellcarcinoma
AT lishauhsuan fdgpetctandendoscopicultrasoundforpreoperativetstagingofesophagealsquamouscellcarcinoma