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FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma
This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better prediction. In total, 100 patients diagnosed with ESCC,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572619/ https://www.ncbi.nlm.nih.gov/pubmed/37835827 http://dx.doi.org/10.3390/diagnostics13193083 |
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author | Huang, Yung-Cheng Chiu, Nan-Tsing Lu, Hung-I Chiu, Yi-Chun Hsu, Chien-Chin Wang, Yu-Ming Li, Shau-Hsuan |
author_facet | Huang, Yung-Cheng Chiu, Nan-Tsing Lu, Hung-I Chiu, Yi-Chun Hsu, Chien-Chin Wang, Yu-Ming Li, Shau-Hsuan |
author_sort | Huang, Yung-Cheng |
collection | PubMed |
description | This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better prediction. In total, 100 patients diagnosed with ESCC, 57 without (CRT([−]sub)) and 43 with (CRT([+]sub)) neoadjuvant chemoradiotherapy, undergoing EUS and FDG PET/CT, followed by surgical resection of the tumor, were included in this analysis. EUS classified T-stages based on the depth of primary tumor invasion, and FDG PET/CT used thresholded maximal standardized uptake value (SUV(max)) classifications. By employing pathology results as the reference standard, we assessed the accuracy of EUS and FDG PET/CT, evaluated their concordance using the κ statistic, and conducted a comparative analysis between the two modalities through McNemar’s chi-square test. FDG PET/CT had higher overall accuracy than EUS (for CRT([−]sub): 71.9%, κ = 0.56 vs. 56.1%, κ = 0.31, p = 0.06; for CRT([+]sub): 65.1%, κ = 0.50 vs. 18.6%, κ = 0.05, p < 0.01) in predicting pT- and ypT-stage. Our proposed method of incorporating both FDG PET/CT and EUS information could achieve higher accuracies in differentiating between early and locally advanced disease in the CRT([−]sub) group (82.5%) and determining residual viable tumor in the CRT([+]sub) group (83.7%) than FDG PET/CT or EUS alone. FDG PET/CT had a better diagnostic ability than EUS to predict the (y)pT-stage of ESCC. Our complementary method, which combines the advantages of both imaging modalities, can deliver higher accuracy for clinical applications of ESCC. |
format | Online Article Text |
id | pubmed-10572619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105726192023-10-14 FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma Huang, Yung-Cheng Chiu, Nan-Tsing Lu, Hung-I Chiu, Yi-Chun Hsu, Chien-Chin Wang, Yu-Ming Li, Shau-Hsuan Diagnostics (Basel) Article This study aimed to compare the diagnostic performances of endoscopic ultrasound (EUS) and FDG PET/CT in the preoperative T-staging of esophageal squamous cell carcinoma (ESCC) and determine whether their innovative coordination achieves better prediction. In total, 100 patients diagnosed with ESCC, 57 without (CRT([−]sub)) and 43 with (CRT([+]sub)) neoadjuvant chemoradiotherapy, undergoing EUS and FDG PET/CT, followed by surgical resection of the tumor, were included in this analysis. EUS classified T-stages based on the depth of primary tumor invasion, and FDG PET/CT used thresholded maximal standardized uptake value (SUV(max)) classifications. By employing pathology results as the reference standard, we assessed the accuracy of EUS and FDG PET/CT, evaluated their concordance using the κ statistic, and conducted a comparative analysis between the two modalities through McNemar’s chi-square test. FDG PET/CT had higher overall accuracy than EUS (for CRT([−]sub): 71.9%, κ = 0.56 vs. 56.1%, κ = 0.31, p = 0.06; for CRT([+]sub): 65.1%, κ = 0.50 vs. 18.6%, κ = 0.05, p < 0.01) in predicting pT- and ypT-stage. Our proposed method of incorporating both FDG PET/CT and EUS information could achieve higher accuracies in differentiating between early and locally advanced disease in the CRT([−]sub) group (82.5%) and determining residual viable tumor in the CRT([+]sub) group (83.7%) than FDG PET/CT or EUS alone. FDG PET/CT had a better diagnostic ability than EUS to predict the (y)pT-stage of ESCC. Our complementary method, which combines the advantages of both imaging modalities, can deliver higher accuracy for clinical applications of ESCC. MDPI 2023-09-28 /pmc/articles/PMC10572619/ /pubmed/37835827 http://dx.doi.org/10.3390/diagnostics13193083 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Yung-Cheng Chiu, Nan-Tsing Lu, Hung-I Chiu, Yi-Chun Hsu, Chien-Chin Wang, Yu-Ming Li, Shau-Hsuan FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma |
title | FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma |
title_full | FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma |
title_fullStr | FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma |
title_full_unstemmed | FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma |
title_short | FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma |
title_sort | fdg pet/ct and endoscopic ultrasound for preoperative t-staging of esophageal squamous cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572619/ https://www.ncbi.nlm.nih.gov/pubmed/37835827 http://dx.doi.org/10.3390/diagnostics13193083 |
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