Cargando…

Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2

The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of unknown significance (p.A868T) on cardiac muscle structure and function. Left ventricular free wall samples were obtaine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodriguez Garcia, Michelle, Schmeckpeper, Jeffrey, Landim-Vieira, Maicon, Coscarella, Isabella Leite, Fang, Xuan, Ma, Weikang, Spran, Payton A., Yuan, Shengyao, Qi, Lin, Kahmini, Aida Rahimi, Shoemaker, M. Benjamin, Atkinson, James B., Kekenes-Huskey, Peter M., Irving, Thomas C., Chase, Prescott Bryant, Knollmann, Björn C., Pinto, Jose Renato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572656/ https://www.ncbi.nlm.nih.gov/pubmed/37834023 http://dx.doi.org/10.3390/ijms241914572

Ejemplares similares

Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function
por: Landim-Vieira, Maicon, et al.
Publicado: (2023)

Nucleus Mechanosensing in Cardiomyocytes
por: Coscarella, Isabella Leite, et al.
Publicado: (2023)

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I
por: Siddiqui, Jalal K., et al.
Publicado: (2016)

EMD-57033 Augments the Contractility in Porcine Myocardium by Promoting the Activation of Myosin in Thick Filaments
por: Jani, Vivek, et al.
Publicado: (2022)

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium
por: Wijnker, Paul J. M., et al.
Publicado: (2011)

Arrhythmogenic Cardiomyopathy: Exercise Pitfalls, Role of Connexin-43, and Moving beyond Antiarrhythmics
por: Coscarella, Isabella Leite, et al.
Publicado: (2022)

Efficacy and Safety of Angiotensin Receptor Blockers in a Pre-Clinical Model of Arrhythmogenic Cardiomyopathy
por: Landim-Vieira, Maicon, et al.
Publicado: (2022)

Transmural Heterogeneity of Myofilament Function and Sarcomeric Protein Phosphorylation in Remodeled Myocardium of Pigs with a Recent Myocardial Infarction
por: van der Velden, Jolanda, et al.
Publicado: (2011)

Molecular Basis of S100A1 Activation and Target Regulation Within Physiological Cytosolic Ca(2+) Levels
por: Sun, Bin, et al.
Publicado: (2020)

Assessing the Role of Calmodulin’s Linker Flexibility in Target Binding
por: Sun, Bin, et al.
Publicado: (2021)

Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium
por: Witayavanitkul, Namthip, et al.
Publicado: (2014)

The Myofilament Lattice: Studies on Isolated Fibers : III. The effect of myofilament spacing upon tension
por: April, Ernest W., et al.
Publicado: (1973)

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure
por: Hessel, Anthony L., et al.
Publicado: (2023)

Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism
por: Lindqvist, Johan, et al.
Publicado: (2020)

A NOTE ON THE STRUCTURE OF CRAYFISH MYOFILAMENTS
por: Peterson, R. Price
Publicado: (1963)

Myofilament function and body mass index
por: Bening, Constanze, et al.
Publicado: (2017)

Dystrophic cardiomyopathy: role of the cardiac myofilaments
por: George, Thomas G., et al.
Publicado: (2023)

Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study
por: Kekenes-Huskey, Peter Michael, et al.
Publicado: (2012)

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy
por: Sequeira, Vasco, et al.
Publicado: (2022)

REVERSIBLE DISAGGREGATION OF MYOFILAMENTS IN VERTEBRATE SMOOTH MUSCLE
por: Fay, Fredric S., et al.
Publicado: (1973)

Diastolic myofilament dysfunction in the failing human heart
por: van der Velden, Jolanda
Publicado: (2011)

Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy
por: Marques, Mayra A., et al.
Publicado: (2021)

Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force
por: Ma, Weikang, et al.
Publicado: (2023)

Co-localization and confinement of ecto-nucleotidases modulate extracellular adenosine nucleotide distributions
por: Rahmaninejad, Hadi, et al.
Publicado: (2020)

The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation
por: Ma, Weikang, et al.
Publicado: (2023)

The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3
por: Agarwal, Sunita K, et al.
Publicado: (2008)

Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of α-actinin
por: Klaavuniemi, Tuula, et al.
Publicado: (2009)

MYOFILAMENTS IN SMOOTH MUSCLE OF GUINEA PIG'S TAENIA COLI
por: Nonomura, Yoshiaki
Publicado: (1968)

Myofibril orientation as a metric for characterizing heart disease
por: Ma, Weikang, et al.
Publicado: (2022)

The fimbrin and alpha-actinin footprint on actin
Publicado: (1994)

An interaction between zyxin and alpha-actinin
Publicado: (1992)

Characterisation of Schizosaccharomyces pombe α-actinin
por: Addario, Barbara, et al.
Publicado: (2016)

Alpha-actinin of the chlorarchiniophyte Bigelowiella natans
por: Backman, Lars
Publicado: (2018)

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A
por: Sevrieva, Ivanka R., et al.
Publicado: (2022)

THE MYOFILAMENT ARRANGEMENT IN THE FEMORAL MUSCLE OF THE COCKROACH, LEUCOPHAEA MADERAE FABRICIUS
por: Hagopian, Martin
Publicado: (1966)

Impact of anesthesia and storage on posttranslational modifications of cardiac myofilament proteins
por: Utter, Megan S, et al.
Publicado: (2015)

Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model
por: Stücker, Sabrina, et al.
Publicado: (2017)

Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts
por: McDonald, Kerry S., et al.
Publicado: (2020)

Inorganic phosphate accelerates cardiac myofilament relaxation in response to lengthening
por: Wakefield, Jane I., et al.
Publicado: (2022)

Dynamics and Calcium Association to the N-Terminal Regulatory Domain of Human Cardiac Troponin C: A Multiscale Computational Study
por: Lindert, Steffen, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nigviqcbi0vq4h8bnttdfp6oqm