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Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2

Background: We aimed to compare the retinal, optic disc vascular density (ODVD) values, and acircularity index (AI) of patients with idiopathic macular telangiectasia type 2 (IMT) and healthy individuals using the optical coherence tomography angiography (OCTA) device. Methods: The study included 39...

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Autores principales: Erol, Muhammet Kazim, Gedik, Birumut, Bozdogan, Yigit Caglar, Ekinci, Rojbin, Bulut, Mehmet, Dogan, Berna, Suren, Elcin, Akidan, Melih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572724/
https://www.ncbi.nlm.nih.gov/pubmed/37835789
http://dx.doi.org/10.3390/diagnostics13193046
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author Erol, Muhammet Kazim
Gedik, Birumut
Bozdogan, Yigit Caglar
Ekinci, Rojbin
Bulut, Mehmet
Dogan, Berna
Suren, Elcin
Akidan, Melih
author_facet Erol, Muhammet Kazim
Gedik, Birumut
Bozdogan, Yigit Caglar
Ekinci, Rojbin
Bulut, Mehmet
Dogan, Berna
Suren, Elcin
Akidan, Melih
author_sort Erol, Muhammet Kazim
collection PubMed
description Background: We aimed to compare the retinal, optic disc vascular density (ODVD) values, and acircularity index (AI) of patients with idiopathic macular telangiectasia type 2 (IMT) and healthy individuals using the optical coherence tomography angiography (OCTA) device. Methods: The study included 39 patients with IMT and 37 healthy controls. The OCTA findings of the patients and controls were examined. Results: The total, parafoveal and perifoveal vascular density of the superficial capillary plexus, choriocapillaris blood flow, inside-disc ODVD, retinal nerve fiber layer (RNFL), and retinal thicknesses were found to be statistically significantly lower, and the foveal avascular zone value was statistically significantly higher in the IMT group compared to the control group (p = 0.001, p = 0.01, p = 0.02, p = 0.01, p = 0.009, p = 0.002, p = 0.02, respectively). There was a statistically significant negative correlation between best-corrected visual acuity (BCVA) and AI (p = 0.02), and a statistically significant positive correlation between peripapillary vascular density and BCVA (p = 0.04). Conclusions: We consider that the lower retinal, choriocapillaris, ODVD values, and retinal and RNFL thicknesses in the patients with IMT compared to the controls were due to vascular damage, remodeling, fibrosis, proliferation, and Müller cell damage. Ellipsoid zone defect, AI, and peripapillary vascular density are important indicators in the evaluation of visual acuity in these patients.
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spelling pubmed-105727242023-10-14 Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2 Erol, Muhammet Kazim Gedik, Birumut Bozdogan, Yigit Caglar Ekinci, Rojbin Bulut, Mehmet Dogan, Berna Suren, Elcin Akidan, Melih Diagnostics (Basel) Article Background: We aimed to compare the retinal, optic disc vascular density (ODVD) values, and acircularity index (AI) of patients with idiopathic macular telangiectasia type 2 (IMT) and healthy individuals using the optical coherence tomography angiography (OCTA) device. Methods: The study included 39 patients with IMT and 37 healthy controls. The OCTA findings of the patients and controls were examined. Results: The total, parafoveal and perifoveal vascular density of the superficial capillary plexus, choriocapillaris blood flow, inside-disc ODVD, retinal nerve fiber layer (RNFL), and retinal thicknesses were found to be statistically significantly lower, and the foveal avascular zone value was statistically significantly higher in the IMT group compared to the control group (p = 0.001, p = 0.01, p = 0.02, p = 0.01, p = 0.009, p = 0.002, p = 0.02, respectively). There was a statistically significant negative correlation between best-corrected visual acuity (BCVA) and AI (p = 0.02), and a statistically significant positive correlation between peripapillary vascular density and BCVA (p = 0.04). Conclusions: We consider that the lower retinal, choriocapillaris, ODVD values, and retinal and RNFL thicknesses in the patients with IMT compared to the controls were due to vascular damage, remodeling, fibrosis, proliferation, and Müller cell damage. Ellipsoid zone defect, AI, and peripapillary vascular density are important indicators in the evaluation of visual acuity in these patients. MDPI 2023-09-25 /pmc/articles/PMC10572724/ /pubmed/37835789 http://dx.doi.org/10.3390/diagnostics13193046 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Erol, Muhammet Kazim
Gedik, Birumut
Bozdogan, Yigit Caglar
Ekinci, Rojbin
Bulut, Mehmet
Dogan, Berna
Suren, Elcin
Akidan, Melih
Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2
title Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2
title_full Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2
title_fullStr Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2
title_full_unstemmed Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2
title_short Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2
title_sort evaluation of optic disc, retinal vascular structures, and acircularity index in patients with idiopathic macular telangiectasia type 2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572724/
https://www.ncbi.nlm.nih.gov/pubmed/37835789
http://dx.doi.org/10.3390/diagnostics13193046
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