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Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study

Introduction: Firefighting foams containing per- and polyfluoroalkyl substances (PFAS) have caused environmental contamination in several Australian residential areas, including Katherine in the Northern Territory (NT), Oakey in Queensland (Qld), and Williamtown in New South Wales (NSW). We examined...

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Autores principales: Law, Hsei Di, Randall, Deborah A., Armstrong, Bruce K., D’este, Catherine, Lazarevic, Nina, Hosking, Rose, Smurthwaite, Kayla S., Trevenar, Susan M., Lucas, Robyn M., Clements, Archie C. A., Kirk, Martyn D., Korda, Rosemary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572760/
https://www.ncbi.nlm.nih.gov/pubmed/37835156
http://dx.doi.org/10.3390/ijerph20196886
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author Law, Hsei Di
Randall, Deborah A.
Armstrong, Bruce K.
D’este, Catherine
Lazarevic, Nina
Hosking, Rose
Smurthwaite, Kayla S.
Trevenar, Susan M.
Lucas, Robyn M.
Clements, Archie C. A.
Kirk, Martyn D.
Korda, Rosemary J.
author_facet Law, Hsei Di
Randall, Deborah A.
Armstrong, Bruce K.
D’este, Catherine
Lazarevic, Nina
Hosking, Rose
Smurthwaite, Kayla S.
Trevenar, Susan M.
Lucas, Robyn M.
Clements, Archie C. A.
Kirk, Martyn D.
Korda, Rosemary J.
author_sort Law, Hsei Di
collection PubMed
description Introduction: Firefighting foams containing per- and polyfluoroalkyl substances (PFAS) have caused environmental contamination in several Australian residential areas, including Katherine in the Northern Territory (NT), Oakey in Queensland (Qld), and Williamtown in New South Wales (NSW). We examined whether the risks of adverse perinatal outcomes were higher in mothers living in these exposure areas than in selected comparison areas without known contamination. Methods: We linked residential addresses in exposure areas to addresses collected in the jurisdictional Perinatal Data Collections of the NT (1986–2017), Qld (2007–2018), and NSW (1994–2018) to select all pregnancies from mothers who gave birth while living in these areas. We also identified one comparison group for each exposure area by selecting pregnancies where the maternal address was in selected comparison areas. We examined 12 binary perinatal outcomes and three growth measurements. For each exposure area, we estimated relative risks (RRs) of adverse outcomes and differences in means of growth measures, adjusting for sociodemographic characteristics and other potential confounders. Results: We included 16,970 pregnancies from the NT, 4654 from Qld, and 7475 from NSW. We observed elevated risks of stillbirth in Oakey (RR = 2.59, 95% confidence interval (CI) 1.25 to 5.39) and of postpartum haemorrhage (RR = 1.94, 95% CI 1.13 to 3.33) and pregnancy-induced hypertension (RR = 1.88, 95% CI 1.30 to 2.73) in Williamtown. The risks of other perinatal outcomes were not materially different from those in the relevant comparison areas or were uncertain due to small numbers of events. Conclusions: There was limited evidence for increased risks of adverse perinatal outcomes in mothers living in areas with PFAS contamination from firefighting foams. We found higher risks of some outcomes in individual areas, but these were not consistent across all areas under study and could have been due to chance, bias, or confounding.
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spelling pubmed-105727602023-10-14 Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study Law, Hsei Di Randall, Deborah A. Armstrong, Bruce K. D’este, Catherine Lazarevic, Nina Hosking, Rose Smurthwaite, Kayla S. Trevenar, Susan M. Lucas, Robyn M. Clements, Archie C. A. Kirk, Martyn D. Korda, Rosemary J. Int J Environ Res Public Health Article Introduction: Firefighting foams containing per- and polyfluoroalkyl substances (PFAS) have caused environmental contamination in several Australian residential areas, including Katherine in the Northern Territory (NT), Oakey in Queensland (Qld), and Williamtown in New South Wales (NSW). We examined whether the risks of adverse perinatal outcomes were higher in mothers living in these exposure areas than in selected comparison areas without known contamination. Methods: We linked residential addresses in exposure areas to addresses collected in the jurisdictional Perinatal Data Collections of the NT (1986–2017), Qld (2007–2018), and NSW (1994–2018) to select all pregnancies from mothers who gave birth while living in these areas. We also identified one comparison group for each exposure area by selecting pregnancies where the maternal address was in selected comparison areas. We examined 12 binary perinatal outcomes and three growth measurements. For each exposure area, we estimated relative risks (RRs) of adverse outcomes and differences in means of growth measures, adjusting for sociodemographic characteristics and other potential confounders. Results: We included 16,970 pregnancies from the NT, 4654 from Qld, and 7475 from NSW. We observed elevated risks of stillbirth in Oakey (RR = 2.59, 95% confidence interval (CI) 1.25 to 5.39) and of postpartum haemorrhage (RR = 1.94, 95% CI 1.13 to 3.33) and pregnancy-induced hypertension (RR = 1.88, 95% CI 1.30 to 2.73) in Williamtown. The risks of other perinatal outcomes were not materially different from those in the relevant comparison areas or were uncertain due to small numbers of events. Conclusions: There was limited evidence for increased risks of adverse perinatal outcomes in mothers living in areas with PFAS contamination from firefighting foams. We found higher risks of some outcomes in individual areas, but these were not consistent across all areas under study and could have been due to chance, bias, or confounding. MDPI 2023-10-05 /pmc/articles/PMC10572760/ /pubmed/37835156 http://dx.doi.org/10.3390/ijerph20196886 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Law, Hsei Di
Randall, Deborah A.
Armstrong, Bruce K.
D’este, Catherine
Lazarevic, Nina
Hosking, Rose
Smurthwaite, Kayla S.
Trevenar, Susan M.
Lucas, Robyn M.
Clements, Archie C. A.
Kirk, Martyn D.
Korda, Rosemary J.
Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study
title Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study
title_full Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study
title_fullStr Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study
title_full_unstemmed Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study
title_short Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study
title_sort relative risks of adverse perinatal outcomes in three australian communities exposed to per- and polyfluoroalkyl substances: data linkage study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572760/
https://www.ncbi.nlm.nih.gov/pubmed/37835156
http://dx.doi.org/10.3390/ijerph20196886
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