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The IFIH1/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early- vs. Late-Onset Skin Disease and Increases the Risk of Arthritis in a Spanish Cohort of Psoriasis

The melanoma differentiation-associated protein 5 (MDA5; encoded by the IFIH1 gene) mediates the activation of the interferon pathway in response to a viral infection. This protein is also upregulated in autoimmune diseases and psoriasis skin lesions. IFIH1 gene variants that increase MDA5 activity...

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Detalles Bibliográficos
Autores principales:	Coto-Segura, Pablo, Vázquez-Coto, Daniel, Velázquez-Cuervo, Lucinda, García-Lago, Claudia, Coto, Eliecer, Queiro, Rubén
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572774/ https://www.ncbi.nlm.nih.gov/pubmed/37834254 http://dx.doi.org/10.3390/ijms241914803

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