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Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy

In the last few decades, RNA-based drugs have emerged as a promising candidate in the treatment of various diseases. The introduction of messenger RNA (mRNA) as a vaccine or therapeutic agent enables the production of almost any functional protein/peptide. The key to applying RNA therapy in clinical...

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Detalles Bibliográficos
Autores principales: Shim, Kyeonghee, Jo, Hyein, Jeoung, Dooil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572814/
https://www.ncbi.nlm.nih.gov/pubmed/37834126
http://dx.doi.org/10.3390/ijms241914679
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author Shim, Kyeonghee
Jo, Hyein
Jeoung, Dooil
author_facet Shim, Kyeonghee
Jo, Hyein
Jeoung, Dooil
author_sort Shim, Kyeonghee
collection PubMed
description In the last few decades, RNA-based drugs have emerged as a promising candidate in the treatment of various diseases. The introduction of messenger RNA (mRNA) as a vaccine or therapeutic agent enables the production of almost any functional protein/peptide. The key to applying RNA therapy in clinical trials is developing safe and effective delivery systems. Exosomes and lipid nanoparticles (LNPs) have been exploited as promising vehicles for drug delivery. This review discusses the feasibility of exosomes and LNPs as vehicles for mRNA delivery. Cancer/testis antigens (CTAs) show restricted expression in normal tissues and widespread expression in cancer tissues. Many of these CTAs show expression in the sera of patients with cancers. These characteristics of CTAs make them excellent targets for cancer immunotherapy. This review summarizes the roles of CTAs in various life processes and current studies on mRNAs encoding CTAs. Clinical studies present the beneficial effects of mRNAs encoding CTAs in patients with cancers. This review highlight clinical studies employing mRNA-LNPs encoding CTAs.
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spelling pubmed-105728142023-10-14 Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy Shim, Kyeonghee Jo, Hyein Jeoung, Dooil Int J Mol Sci Review In the last few decades, RNA-based drugs have emerged as a promising candidate in the treatment of various diseases. The introduction of messenger RNA (mRNA) as a vaccine or therapeutic agent enables the production of almost any functional protein/peptide. The key to applying RNA therapy in clinical trials is developing safe and effective delivery systems. Exosomes and lipid nanoparticles (LNPs) have been exploited as promising vehicles for drug delivery. This review discusses the feasibility of exosomes and LNPs as vehicles for mRNA delivery. Cancer/testis antigens (CTAs) show restricted expression in normal tissues and widespread expression in cancer tissues. Many of these CTAs show expression in the sera of patients with cancers. These characteristics of CTAs make them excellent targets for cancer immunotherapy. This review summarizes the roles of CTAs in various life processes and current studies on mRNAs encoding CTAs. Clinical studies present the beneficial effects of mRNAs encoding CTAs in patients with cancers. This review highlight clinical studies employing mRNA-LNPs encoding CTAs. MDPI 2023-09-28 /pmc/articles/PMC10572814/ /pubmed/37834126 http://dx.doi.org/10.3390/ijms241914679 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shim, Kyeonghee
Jo, Hyein
Jeoung, Dooil
Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy
title Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy
title_full Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy
title_fullStr Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy
title_full_unstemmed Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy
title_short Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy
title_sort cancer/testis antigens as targets for rna-based anticancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572814/
https://www.ncbi.nlm.nih.gov/pubmed/37834126
http://dx.doi.org/10.3390/ijms241914679
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