Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review

Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms,...

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Detalles Bibliográficos
Autores principales: Zelada, Mario Ignacio, Garrido, Verónica, Liberona, Andrés, Jones, Natalia, Zúñiga, Karen, Silva, Hernán, Nieto, Rodrigo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572866/
https://www.ncbi.nlm.nih.gov/pubmed/37834258
http://dx.doi.org/10.3390/ijms241914810
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author Zelada, Mario Ignacio
Garrido, Verónica
Liberona, Andrés
Jones, Natalia
Zúñiga, Karen
Silva, Hernán
Nieto, Rodrigo R.
author_facet Zelada, Mario Ignacio
Garrido, Verónica
Liberona, Andrés
Jones, Natalia
Zúñiga, Karen
Silva, Hernán
Nieto, Rodrigo R.
author_sort Zelada, Mario Ignacio
collection PubMed
description Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms, with response to treatment in MDD. In order to achieve this, we performed a systematic review of studies that explored the relation of BDNF with both pharmacological and non-pharmacological treatment. Finally, we reviewed the evidence that relates peripheral levels of BDNF and BDNF polymorphisms with the development and management of treatment-resistant depression.
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spelling pubmed-105728662023-10-14 Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review Zelada, Mario Ignacio Garrido, Verónica Liberona, Andrés Jones, Natalia Zúñiga, Karen Silva, Hernán Nieto, Rodrigo R. Int J Mol Sci Review Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms, with response to treatment in MDD. In order to achieve this, we performed a systematic review of studies that explored the relation of BDNF with both pharmacological and non-pharmacological treatment. Finally, we reviewed the evidence that relates peripheral levels of BDNF and BDNF polymorphisms with the development and management of treatment-resistant depression. MDPI 2023-09-30 /pmc/articles/PMC10572866/ /pubmed/37834258 http://dx.doi.org/10.3390/ijms241914810 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zelada, Mario Ignacio
Garrido, Verónica
Liberona, Andrés
Jones, Natalia
Zúñiga, Karen
Silva, Hernán
Nieto, Rodrigo R.
Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review
title Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review
title_full Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review
title_fullStr Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review
title_full_unstemmed Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review
title_short Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review
title_sort brain-derived neurotrophic factor (bdnf) as a predictor of treatment response in major depressive disorder (mdd): a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572866/
https://www.ncbi.nlm.nih.gov/pubmed/37834258
http://dx.doi.org/10.3390/ijms241914810
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