Cargando…

PIP5Kγ Mediates PI(4,5)P2/Merlin/LATS1 Signaling Activation and Interplays with Hsc70 in Hippo–YAP Pathway Regulation

The type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family produces the critical lipid regulator phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in the plasma membrane (PM). Here, we investigated the potential role of PIP5Kγ, a PIP5K isoform, in the Hippo pathway. The ectopic expression o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Le, Duong Duy Thai, Le, Truc Phan Hoang, Lee, Sang Yoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572892/ https://www.ncbi.nlm.nih.gov/pubmed/37834234 http://dx.doi.org/10.3390/ijms241914786

Ejemplares similares

Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1
por: Le, Truc Phan Hoang, et al.
Publicado: (2023)

Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
por: Mindos, Thomas, et al.
Publicado: (2017)

Effects of Quinacrine on Expression of Hippo signaling Pathway Components (LATS1, LATS2, and YAP) in Human Breast Cancer Stem Cells
por: Darbankhales, Soroush, et al.
Publicado: (2020)

Merlin tumor suppressor function is regulated by PIP(2)-mediated dimerization
por: Hennigan, Robert F., et al.
Publicado: (2023)

Protocols for measuring phosphorylation, subcellular localization, and kinase activity of Hippo pathway components YAP and LATS in cultured cells
por: Luo, Min, et al.
Publicado: (2022)

Hippo Pathway Phylogenetics Predicts Monoubiquitylation of Salvador and Merlin/Nf2
por: Wisotzkey, Robert G., et al.
Publicado: (2012)

Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
por: Li, Youjun, et al.
Publicado: (2015)

Hsc70’s trip to the tip
por: Leslie, Mitch
Publicado: (2015)

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly
por: Xing, Yi, et al.
Publicado: (2010)

Comparative analysis of the anticoagulant activities and immunogenicity of HSC70 and HSC70(TKD) of Haemaphysalis flava
por: Liu, Yu-Ke, et al.
Publicado: (2022)

Molecular regulation of trophoblast stem cell self-renewal and giant cell differentiation by the Hippo components YAP and LATS1
por: Basak, Trishita, et al.
Publicado: (2022)

Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase–mediated inhibitory phosphorylation of the transcriptional coactivator YAP
por: Thines, Louise, et al.
Publicado: (2022)

The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis
por: Zinatizadeh, Mohammad Reza, et al.
Publicado: (2019)

Merlin, a regulator of Hippo signaling, regulates Wnt/β-catenin signaling
por: Kim, Soyoung, et al.
Publicado: (2016)

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
por: Lo, Wan-Lin, et al.
Publicado: (2018)

RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer
por: Pan, Yi, et al.
Publicado: (2018)

Platycodin D confers oxaliplatin Resistance in Colorectal Cancer by activating the LATS2/YAP1 axis of the hippo signaling pathway
por: Wang, Chien-Hao, et al.
Publicado: (2023)

Hippo-Yap Pathway Orchestrates Neural Crest Ontogenesis
por: Zhao, Xiaolei, et al.
Publicado: (2021)

Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2
por: Yuan, T, et al.
Publicado: (2016)

YAP and the Hippo pathway in cholangiocarcinoma
por: Sugihara, Takaaki, et al.
Publicado: (2019)

How is SR calcium release in muscle modulated by PIP(4,5)(2)?
por: Flucher, Bernhard E.
Publicado: (2015)

Intercellular interaction dictates cancer cell ferroptosis via Merlin-YAP signalling
por: Wu, Jiao, et al.
Publicado: (2019)

Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling
por: Hu, Xiaohan, et al.
Publicado: (2023)

CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence
por: Li, Luhua, et al.
Publicado: (2016)

Downregulation of microRNA-224-3p Hampers Retinoblastoma Progression via Activation of the Hippo-YAP Signaling Pathway by Increasing LATS2
por: Song, Lili, et al.
Publicado: (2020)

MicroRNA-93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarction
por: Ma, Chengjie, et al.
Publicado: (2020)

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts
por: Jahanshahi, Maryam, et al.
Publicado: (2016)

Merlín /
por: Lawhead, Steve
Publicado: (1996)

Merlín
por: Rio, Michel
Publicado: (1995)

Hippo-YAP/TAZ signaling in angiogenesis
por: Park, Jeong Ae, et al.
Publicado: (2018)

A dPIP5K Dependent Pool of Phosphatidylinositol 4,5 Bisphosphate (PIP(2)) Is Required for G-Protein Coupled Signal Transduction in Drosophila Photoreceptors
por: Chakrabarti, Purbani, et al.
Publicado: (2015)

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
por: Dobrokhotov, Oleg, et al.
Publicado: (2018)

Hippo signaling dysfunction induces cancer cell addiction to YAP
por: Han, Han, et al.
Publicado: (2018)

Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling
por: An, Yang, et al.
Publicado: (2013)

POPX2 is a novel LATS phosphatase that regulates the Hippo pathway
por: Rahmat, Muhammad Bakhait, et al.
Publicado: (2019)

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2
por: Park, Gun-Soo, et al.
Publicado: (2016)

Hsc70 is required for endocytosis and clathrin function in Drosophila
por: Chang, Henry C., et al.
Publicado: (2002)

Mechanism and Complex Roles of HSC70 in Viral Infections
por: Wang, Zeng, et al.
Publicado: (2020)

Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70
por: Hong, Zhouping, et al.
Publicado: (2022)

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity
por: Xie, Jia, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_cmqq01h8lhtov1g8eq1va0le58