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Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus

This review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer’s disease. The pathogenesis of Alzheimer’s disease closely intersects with the mechanisms of type 2 diabetes development, and an important risk factor for b...

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Autores principales: Veselov, Ivan M., Vinogradova, Daria V., Maltsev, Andrey V., Shevtsov, Pavel N., Spirkova, Elena A., Bachurin, Sergey O., Shevtsova, Elena F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572926/
https://www.ncbi.nlm.nih.gov/pubmed/37833898
http://dx.doi.org/10.3390/ijms241914450
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author Veselov, Ivan M.
Vinogradova, Daria V.
Maltsev, Andrey V.
Shevtsov, Pavel N.
Spirkova, Elena A.
Bachurin, Sergey O.
Shevtsova, Elena F.
author_facet Veselov, Ivan M.
Vinogradova, Daria V.
Maltsev, Andrey V.
Shevtsov, Pavel N.
Spirkova, Elena A.
Bachurin, Sergey O.
Shevtsova, Elena F.
author_sort Veselov, Ivan M.
collection PubMed
description This review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer’s disease. The pathogenesis of Alzheimer’s disease closely intersects with the mechanisms of type 2 diabetes development, and an important risk factor for both pathologies is aging. Common pathological mechanisms include both factors in the development of oxidative stress, neuroinflammation, insulin resistance, and amyloidosis, as well as impaired mitochondrial dysfunctions and increasing cell death. The currently available drugs for the treatment of type 2 diabetes and Alzheimer’s disease have limited therapeutic efficacy. It is important to note that drugs used to treat Alzheimer’s disease, in particular acetylcholinesterase inhibitors, show a positive therapeutic potential in the treatment of type 2 diabetes, while drugs used in the treatment of type 2 diabetes can also prevent a number of pathologies characteristic for Alzheimer’s disease. A promising direction in the search for a strategy for the treatment of type 2 diabetes and Alzheimer’s disease may be the creation of complex multi-target drugs that have neuroprotective potential and affect specific common targets for type 2 diabetes and Alzheimer’s disease.
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spelling pubmed-105729262023-10-14 Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus Veselov, Ivan M. Vinogradova, Daria V. Maltsev, Andrey V. Shevtsov, Pavel N. Spirkova, Elena A. Bachurin, Sergey O. Shevtsova, Elena F. Int J Mol Sci Review This review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer’s disease. The pathogenesis of Alzheimer’s disease closely intersects with the mechanisms of type 2 diabetes development, and an important risk factor for both pathologies is aging. Common pathological mechanisms include both factors in the development of oxidative stress, neuroinflammation, insulin resistance, and amyloidosis, as well as impaired mitochondrial dysfunctions and increasing cell death. The currently available drugs for the treatment of type 2 diabetes and Alzheimer’s disease have limited therapeutic efficacy. It is important to note that drugs used to treat Alzheimer’s disease, in particular acetylcholinesterase inhibitors, show a positive therapeutic potential in the treatment of type 2 diabetes, while drugs used in the treatment of type 2 diabetes can also prevent a number of pathologies characteristic for Alzheimer’s disease. A promising direction in the search for a strategy for the treatment of type 2 diabetes and Alzheimer’s disease may be the creation of complex multi-target drugs that have neuroprotective potential and affect specific common targets for type 2 diabetes and Alzheimer’s disease. MDPI 2023-09-22 /pmc/articles/PMC10572926/ /pubmed/37833898 http://dx.doi.org/10.3390/ijms241914450 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Veselov, Ivan M.
Vinogradova, Daria V.
Maltsev, Andrey V.
Shevtsov, Pavel N.
Spirkova, Elena A.
Bachurin, Sergey O.
Shevtsova, Elena F.
Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus
title Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus
title_full Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus
title_fullStr Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus
title_full_unstemmed Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus
title_short Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus
title_sort mitochondria and oxidative stress as a link between alzheimer’s disease and diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572926/
https://www.ncbi.nlm.nih.gov/pubmed/37833898
http://dx.doi.org/10.3390/ijms241914450
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