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The Diagnosis and Management of Cutaneous Metastases from Melanoma
Melanoma is one of the deadliest skin tumors, accounting for almost 90% of skin cancer mortality. Although immune therapy and targeted therapy have dramatically changed the prognosis of metastatic melanoma, many patients experience disease progression despite the currently available new treatments....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572973/ https://www.ncbi.nlm.nih.gov/pubmed/37833981 http://dx.doi.org/10.3390/ijms241914535 |
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author | Di Raimondo, Cosimo Lozzi, Flavia Di Domenico, Pier Paolo Campione, Elena Bianchi, Luca |
author_facet | Di Raimondo, Cosimo Lozzi, Flavia Di Domenico, Pier Paolo Campione, Elena Bianchi, Luca |
author_sort | Di Raimondo, Cosimo |
collection | PubMed |
description | Melanoma is one of the deadliest skin tumors, accounting for almost 90% of skin cancer mortality. Although immune therapy and targeted therapy have dramatically changed the prognosis of metastatic melanoma, many patients experience disease progression despite the currently available new treatments. Skin metastases from melanoma represent a relatively common event as first sign of advanced disease or a sign of recurrence. Skin metastases are usually asymptomatic, although in advanced stages, they can present with ulceration, bleeding, and superinfection; furthermore, they can cause symptoms related to compression on nearby tissues. Treatments vary from simple surgery resections to topical or intralesional local injections, or a combination of these techniques with the most recent systemic immune or target therapies. New research and studies should focus on the pathogenesis and molecular mechanisms of the cutaneous metastases of melanoma in order to shed light on the mechanisms underlying the different behavior and prognoses of different patients. |
format | Online Article Text |
id | pubmed-10572973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105729732023-10-14 The Diagnosis and Management of Cutaneous Metastases from Melanoma Di Raimondo, Cosimo Lozzi, Flavia Di Domenico, Pier Paolo Campione, Elena Bianchi, Luca Int J Mol Sci Review Melanoma is one of the deadliest skin tumors, accounting for almost 90% of skin cancer mortality. Although immune therapy and targeted therapy have dramatically changed the prognosis of metastatic melanoma, many patients experience disease progression despite the currently available new treatments. Skin metastases from melanoma represent a relatively common event as first sign of advanced disease or a sign of recurrence. Skin metastases are usually asymptomatic, although in advanced stages, they can present with ulceration, bleeding, and superinfection; furthermore, they can cause symptoms related to compression on nearby tissues. Treatments vary from simple surgery resections to topical or intralesional local injections, or a combination of these techniques with the most recent systemic immune or target therapies. New research and studies should focus on the pathogenesis and molecular mechanisms of the cutaneous metastases of melanoma in order to shed light on the mechanisms underlying the different behavior and prognoses of different patients. MDPI 2023-09-26 /pmc/articles/PMC10572973/ /pubmed/37833981 http://dx.doi.org/10.3390/ijms241914535 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Raimondo, Cosimo Lozzi, Flavia Di Domenico, Pier Paolo Campione, Elena Bianchi, Luca The Diagnosis and Management of Cutaneous Metastases from Melanoma |
title | The Diagnosis and Management of Cutaneous Metastases from Melanoma |
title_full | The Diagnosis and Management of Cutaneous Metastases from Melanoma |
title_fullStr | The Diagnosis and Management of Cutaneous Metastases from Melanoma |
title_full_unstemmed | The Diagnosis and Management of Cutaneous Metastases from Melanoma |
title_short | The Diagnosis and Management of Cutaneous Metastases from Melanoma |
title_sort | diagnosis and management of cutaneous metastases from melanoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572973/ https://www.ncbi.nlm.nih.gov/pubmed/37833981 http://dx.doi.org/10.3390/ijms241914535 |
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