Bortezomib Is Effective in the Treatment of T Lymphoblastic Leukaemia by Inducing DNA Damage, WEE1 Downregulation, and Mitotic Catastrophe

T lymphoblastic leukemia (T-ALL) is an aggressive haematolymphoid malignancy comprising 15% of acute lymphoblastic leukemia (ALL). Although its prognosis has improved with intensive chemotherapy, the relapse/refractory disease still carries a dismal prognosis. Thus, there is an urgent need to develo...

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Detalles Bibliográficos
Autores principales: Din, Rahman Ud, Jiao, Anan, Qiu, Yinxia, Mohan, Aarmann Anil Mohinani, Yuen, Kei-Ching, Wong, Hoi-Tung, Wan, Timothy Ming-Hun, Wong, Phoebe On-Yi, Sin, Chun-Fung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10572992/
https://www.ncbi.nlm.nih.gov/pubmed/37834095
http://dx.doi.org/10.3390/ijms241914646

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