To Break or Not to Break: The Role of TOP2B in Transcription

Transcription and its regulation pose challenges related to DNA torsion and supercoiling of the DNA template. RNA polymerase tracking the helical groove of the DNA introduces positive helical torsion and supercoiling upstream and negative torsion and supercoiling behind its direction of travel. This...

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Detalles Bibliográficos
Autores principales: Cowell, Ian G., Casement, John W., Austin, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573011/
https://www.ncbi.nlm.nih.gov/pubmed/37834253
http://dx.doi.org/10.3390/ijms241914806

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