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IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond

Inflammatory Bowel Disease (IBD) presents distinct challenges during pregnancy due to its influence on maternal health and pregnancy outcomes. This literature review aims to dissect the existing scientific evidence on pregnancy in women with IBD and provide evidence-based recommendations for clinica...

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Detalles Bibliográficos
Autores principales: Caballero-Mateos, Antonio M., Quesada-Caballero, Miguel, Cañadas-De la Fuente, Guillermo A., Caballero-Vázquez, Alberto, Contreras-Chova, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573266/
https://www.ncbi.nlm.nih.gov/pubmed/37834837
http://dx.doi.org/10.3390/jcm12196192
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author Caballero-Mateos, Antonio M.
Quesada-Caballero, Miguel
Cañadas-De la Fuente, Guillermo A.
Caballero-Vázquez, Alberto
Contreras-Chova, Francisco
author_facet Caballero-Mateos, Antonio M.
Quesada-Caballero, Miguel
Cañadas-De la Fuente, Guillermo A.
Caballero-Vázquez, Alberto
Contreras-Chova, Francisco
author_sort Caballero-Mateos, Antonio M.
collection PubMed
description Inflammatory Bowel Disease (IBD) presents distinct challenges during pregnancy due to its influence on maternal health and pregnancy outcomes. This literature review aims to dissect the existing scientific evidence on pregnancy in women with IBD and provide evidence-based recommendations for clinical management. A comprehensive search was conducted across scientific databases, selecting clinical studies, systematic reviews, and other pertinent resources. Numerous studies have underscored an increased risk of complications during pregnancy for women with IBD, including preterm birth, low birth weight, neonates small for gestational age, and congenital malformations. Nevertheless, it’s evident that proactive disease management before and throughout pregnancy can mitigate these risks. Continuation of IBD treatment during pregnancy and breastfeeding is deemed safe with agents like thiopurines, anti-TNF, vedolizumab, or ustekinumab. However, there’s a call for caution when combining treatments due to the heightened risk of severe infections in the first year of life. For small molecules, their use is advised against in both scenarios. Effective disease management, minimizing disease activity, and interdisciplinary care are pivotal in attending to women with IBD. The emphasis is placed on the continual assessment of maternal and infant outcomes and an expressed need for further research to enhance the understanding of the ties between IBD and adverse pregnancy outcomes.
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spelling pubmed-105732662023-10-14 IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond Caballero-Mateos, Antonio M. Quesada-Caballero, Miguel Cañadas-De la Fuente, Guillermo A. Caballero-Vázquez, Alberto Contreras-Chova, Francisco J Clin Med Review Inflammatory Bowel Disease (IBD) presents distinct challenges during pregnancy due to its influence on maternal health and pregnancy outcomes. This literature review aims to dissect the existing scientific evidence on pregnancy in women with IBD and provide evidence-based recommendations for clinical management. A comprehensive search was conducted across scientific databases, selecting clinical studies, systematic reviews, and other pertinent resources. Numerous studies have underscored an increased risk of complications during pregnancy for women with IBD, including preterm birth, low birth weight, neonates small for gestational age, and congenital malformations. Nevertheless, it’s evident that proactive disease management before and throughout pregnancy can mitigate these risks. Continuation of IBD treatment during pregnancy and breastfeeding is deemed safe with agents like thiopurines, anti-TNF, vedolizumab, or ustekinumab. However, there’s a call for caution when combining treatments due to the heightened risk of severe infections in the first year of life. For small molecules, their use is advised against in both scenarios. Effective disease management, minimizing disease activity, and interdisciplinary care are pivotal in attending to women with IBD. The emphasis is placed on the continual assessment of maternal and infant outcomes and an expressed need for further research to enhance the understanding of the ties between IBD and adverse pregnancy outcomes. MDPI 2023-09-25 /pmc/articles/PMC10573266/ /pubmed/37834837 http://dx.doi.org/10.3390/jcm12196192 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Caballero-Mateos, Antonio M.
Quesada-Caballero, Miguel
Cañadas-De la Fuente, Guillermo A.
Caballero-Vázquez, Alberto
Contreras-Chova, Francisco
IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond
title IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond
title_full IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond
title_fullStr IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond
title_full_unstemmed IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond
title_short IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond
title_sort ibd and motherhood: a journey through conception, pregnancy and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573266/
https://www.ncbi.nlm.nih.gov/pubmed/37834837
http://dx.doi.org/10.3390/jcm12196192
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