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The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status

Uncontrolled acromegaly causes increased morbidity and mortality. The analysis of acromegaly comorbidities and complications is important when establishing a standard of care for the entire population of acromegaly patients. The aim of this study was to determine the frequency of comorbidities and c...

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Autores principales: Elbaum, Michał, Kałużny, Marcin, Jawiarczyk-Przybyłowska, Aleksandra, Wojtczak, Beata, Zieliński, Grzegorz, Bolanowski, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573270/
https://www.ncbi.nlm.nih.gov/pubmed/37834952
http://dx.doi.org/10.3390/jcm12196309
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author Elbaum, Michał
Kałużny, Marcin
Jawiarczyk-Przybyłowska, Aleksandra
Wojtczak, Beata
Zieliński, Grzegorz
Bolanowski, Marek
author_facet Elbaum, Michał
Kałużny, Marcin
Jawiarczyk-Przybyłowska, Aleksandra
Wojtczak, Beata
Zieliński, Grzegorz
Bolanowski, Marek
author_sort Elbaum, Michał
collection PubMed
description Uncontrolled acromegaly causes increased morbidity and mortality. The analysis of acromegaly comorbidities and complications is important when establishing a standard of care for the entire population of acromegaly patients. The aim of this study was to determine the frequency of comorbidities and complications of acromegaly and their dependence on the activity of the disease. A retrospective analysis of medical records from 124 patients with acromegaly was carried out, including 39 who were cured, 73 treated with somatostatin analogs and 12 newly diagnosed patients. The incidence of comorbidities and complications was very high, and those most frequently observed were arterial hypertension, multinodular goiter, lipid disorders, hypopituitarism and degenerative changes. At least one complication of acromegaly was observed in 92% of patients undergoing successful neurosurgery and in all pharmacologically treated patients. By contrast, two or more complications were observed in 77% of cured patients and in pharmacologically controlled and uncontrolled patients, 82% and 91%, respectively. Conclusions: Acromegaly is associated with a high prevalence of complications. Active acromegaly is associated with a higher incidence of complications than in treated groups. Untreated patients have more complications than treated patients. Successfully cured patients have significantly fewer complications than pharmacologically controlled patients and patients with active acromegaly.
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spelling pubmed-105732702023-10-14 The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status Elbaum, Michał Kałużny, Marcin Jawiarczyk-Przybyłowska, Aleksandra Wojtczak, Beata Zieliński, Grzegorz Bolanowski, Marek J Clin Med Article Uncontrolled acromegaly causes increased morbidity and mortality. The analysis of acromegaly comorbidities and complications is important when establishing a standard of care for the entire population of acromegaly patients. The aim of this study was to determine the frequency of comorbidities and complications of acromegaly and their dependence on the activity of the disease. A retrospective analysis of medical records from 124 patients with acromegaly was carried out, including 39 who were cured, 73 treated with somatostatin analogs and 12 newly diagnosed patients. The incidence of comorbidities and complications was very high, and those most frequently observed were arterial hypertension, multinodular goiter, lipid disorders, hypopituitarism and degenerative changes. At least one complication of acromegaly was observed in 92% of patients undergoing successful neurosurgery and in all pharmacologically treated patients. By contrast, two or more complications were observed in 77% of cured patients and in pharmacologically controlled and uncontrolled patients, 82% and 91%, respectively. Conclusions: Acromegaly is associated with a high prevalence of complications. Active acromegaly is associated with a higher incidence of complications than in treated groups. Untreated patients have more complications than treated patients. Successfully cured patients have significantly fewer complications than pharmacologically controlled patients and patients with active acromegaly. MDPI 2023-09-30 /pmc/articles/PMC10573270/ /pubmed/37834952 http://dx.doi.org/10.3390/jcm12196309 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elbaum, Michał
Kałużny, Marcin
Jawiarczyk-Przybyłowska, Aleksandra
Wojtczak, Beata
Zieliński, Grzegorz
Bolanowski, Marek
The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status
title The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status
title_full The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status
title_fullStr The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status
title_full_unstemmed The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status
title_short The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status
title_sort relationship between the burden of acromegaly, associated comorbidities, complications and disease status
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573270/
https://www.ncbi.nlm.nih.gov/pubmed/37834952
http://dx.doi.org/10.3390/jcm12196309
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