Cargando…
The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome
This study aimed to explore the potential association between the triglyceride–glucose index (TyG) and the atherogenic index of plasma (AIP)—both considered surrogate markers for atherosclerosis—and major adverse cardiovascular events (MACEs) in patients diagnosed with chronic coronary syndrome (CCS...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573341/ https://www.ncbi.nlm.nih.gov/pubmed/37834844 http://dx.doi.org/10.3390/jcm12196201 |
_version_ | 1785120439707631616 |
---|---|
author | Erdoğan, Aslan İnan, Duygu Genç, Ömer Yıldız, Ufuk Demirtola, Ayşe İrem Çetin, İlyas Güler, Yeliz Tekin, Ali Fuat Barutçu, Süleyman Güler, Ahmet Karagöz, Ali |
author_facet | Erdoğan, Aslan İnan, Duygu Genç, Ömer Yıldız, Ufuk Demirtola, Ayşe İrem Çetin, İlyas Güler, Yeliz Tekin, Ali Fuat Barutçu, Süleyman Güler, Ahmet Karagöz, Ali |
author_sort | Erdoğan, Aslan |
collection | PubMed |
description | This study aimed to explore the potential association between the triglyceride–glucose index (TyG) and the atherogenic index of plasma (AIP)—both considered surrogate markers for atherosclerosis—and major adverse cardiovascular events (MACEs) in patients diagnosed with chronic coronary syndrome (CCS). We conducted a retrospective analysis, encompassing 715 consecutive patients with intermediate CCS risk, who presented at the outpatient clinic between June 2020 and August 2022. MACEs included non-fatal myocardial infarction, hospitalization for heart failure, cerebrovascular events, non-cardiac mortality, and cardiac mortality. The primary outcome was the composite occurrence of MACEs during the follow-up period. For time-to-event analysis of the primary outcome, we employed Kaplan–Meier plots and Cox proportional hazard models. The median age of the overall study population was 55 years, with a median follow-up duration of 17 months. Multivariate Cox regression analysis identified age, hypertension, Coronary Artery Disease–Reporting and Data System score, and TyG index as independent predictors of the primary outcome. Notably, individuals with high TyG levels exhibited a significantly higher primary outcome rate compared to those with low TyG levels (18.7% vs. 3.8%, p < 0.001). Similarly, patients with elevated TyG values demonstrated statistically higher rates of cerebrovascular events, hospitalizations for heart failure, non-fatal myocardial infarctions, non-cardiac mortality, and cardiac mortality. These findings suggest that TyG may serve as a predictive marker for adverse cardiovascular outcomes in patients with CCS. |
format | Online Article Text |
id | pubmed-10573341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105733412023-10-14 The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome Erdoğan, Aslan İnan, Duygu Genç, Ömer Yıldız, Ufuk Demirtola, Ayşe İrem Çetin, İlyas Güler, Yeliz Tekin, Ali Fuat Barutçu, Süleyman Güler, Ahmet Karagöz, Ali J Clin Med Article This study aimed to explore the potential association between the triglyceride–glucose index (TyG) and the atherogenic index of plasma (AIP)—both considered surrogate markers for atherosclerosis—and major adverse cardiovascular events (MACEs) in patients diagnosed with chronic coronary syndrome (CCS). We conducted a retrospective analysis, encompassing 715 consecutive patients with intermediate CCS risk, who presented at the outpatient clinic between June 2020 and August 2022. MACEs included non-fatal myocardial infarction, hospitalization for heart failure, cerebrovascular events, non-cardiac mortality, and cardiac mortality. The primary outcome was the composite occurrence of MACEs during the follow-up period. For time-to-event analysis of the primary outcome, we employed Kaplan–Meier plots and Cox proportional hazard models. The median age of the overall study population was 55 years, with a median follow-up duration of 17 months. Multivariate Cox regression analysis identified age, hypertension, Coronary Artery Disease–Reporting and Data System score, and TyG index as independent predictors of the primary outcome. Notably, individuals with high TyG levels exhibited a significantly higher primary outcome rate compared to those with low TyG levels (18.7% vs. 3.8%, p < 0.001). Similarly, patients with elevated TyG values demonstrated statistically higher rates of cerebrovascular events, hospitalizations for heart failure, non-fatal myocardial infarctions, non-cardiac mortality, and cardiac mortality. These findings suggest that TyG may serve as a predictive marker for adverse cardiovascular outcomes in patients with CCS. MDPI 2023-09-26 /pmc/articles/PMC10573341/ /pubmed/37834844 http://dx.doi.org/10.3390/jcm12196201 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Erdoğan, Aslan İnan, Duygu Genç, Ömer Yıldız, Ufuk Demirtola, Ayşe İrem Çetin, İlyas Güler, Yeliz Tekin, Ali Fuat Barutçu, Süleyman Güler, Ahmet Karagöz, Ali The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome |
title | The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome |
title_full | The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome |
title_fullStr | The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome |
title_full_unstemmed | The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome |
title_short | The Triglyceride–Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome |
title_sort | triglyceride–glucose index might be a better indicator for predicting poor cardiovascular outcomes in chronic coronary syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573341/ https://www.ncbi.nlm.nih.gov/pubmed/37834844 http://dx.doi.org/10.3390/jcm12196201 |
work_keys_str_mv | AT erdoganaslan thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT inanduygu thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT gencomer thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT yıldızufuk thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT demirtolaayseirem thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT cetinilyas thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT guleryeliz thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT tekinalifuat thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT barutcusuleyman thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT gulerahmet thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT karagozali thetriglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT erdoganaslan triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT inanduygu triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT gencomer triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT yıldızufuk triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT demirtolaayseirem triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT cetinilyas triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT guleryeliz triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT tekinalifuat triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT barutcusuleyman triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT gulerahmet triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome AT karagozali triglycerideglucoseindexmightbeabetterindicatorforpredictingpoorcardiovascularoutcomesinchroniccoronarysyndrome |